C5a受体颉颃剂及其在动物疾病模型治疗中的研究进展  

Research Progress on C5a Receptor Antagonists and their Treatment in Animal Disease Model

作　　者：张泽英[1,2] 刘东旭[2] 

机构地区：[1]武汉生物工程学院食品工程系,湖北武汉430015 [2]湖北大学生命科学学院,湖北武汉430062

出　　处：《中国畜牧兽医》2014年第2期158-163,共6页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金(31070776)

摘　　要：C5a受体是人和动物体内补体系统的重要组成部分,与C5a结合后介导了众多生物学效应,参与了许多疾病的发生、发展,并在多种病变中起重要作用,如器官缺血再灌注损伤、急性肺损伤、脓毒血症、类风湿性关节炎、肾小球肾炎等疾病。如何抑制C5a受体的生物活性,从而减轻炎症反应一直是免疫学研究的热点问题。文章着重介绍了C5a受体颉颃剂及其在动物疾病模型治疗中的研究进展。As a key part of the complement system in human and animal body, CSa receptor combined with C5a has been considered to mediate numerous biological processes and be involved in the pathology of numerous inflammatory diseases, such as ischemia-reperfusion injury, acute lung injury, sepsis, rheumatoid arthritis and glomerular nephritis. Therefore, current studies focus on how to block CSa receptor and dampen the inflammatory reaction. This review provides a brief overview of the current development of CSa receptor antagonists and their treatment in animal disease model.

关 键 词：C5A C5A受体 颉颃剂 补体 治疗 

分 类 号：S852.4[农业科学—基础兽医学]