血清降钙素原和C-反应蛋白水平对危重症患儿预后的意义  

Significances of serum procalcitonin and C-reactive protein levels on prognosis of critically ill children

作　　者：姜明宇[1] 司利钢[1] 徐向平[1] 张剑白[1] 张秋月[1] 杜萍[1] 

机构地区：[1]哈尔滨医科大学附属第一医院儿科,黑龙江哈尔滨150001

出　　处：《中国妇幼保健》2014年第6期880-882,共3页Maternal and Child Health Care of China

基　　金：黑龙江省自然科学基金〔D2007-43〕

摘　　要：目的：分别对儿童危重症患者血清降钙素原和C-反应蛋白水平与预后的关系进行研究，探讨两者与危重症患者预后的关系。方法：回顾性分析2011年1月～2013年6月入住哈尔滨医科大学附属第一医院新生儿重症监护病房与儿科重症监护病房的108例患者，依据其入院时血清降钙素原和C-反应蛋白水平的测定值分别进行分组，计算病死率，并且进行统计学比较。血清降钙素原水平以0．5μg／L、2．0μg／L和10．0μg／L为界分为4组。血清C-反应蛋白水平以10mg／L与50mg／L为界分为3组。结果：患儿的病死率随血清降钙素原水平升高而增高（P〈0．05）；而在C-反应蛋白的分析中，高水平的C-反应蛋白患儿与正常C-反应蛋白患儿相比，病死率无统计学差异（P〉0．05）。结论：儿童危重症患儿血清降钙素原水平与患儿预后关系密切。Objective： To explore the relationship between serum procalcitonin, C -reactive protein levels and prognosis of critically ill children. Methods： A total of 108 critically ill children trom neonatal intensive care unit （NICU） and pediatric intensive care unit （PICU） in the hospital from January 2011 to June 2013 were analyzed retrospectively, and then they were divided into different groups according to the detection results of serum procalcitonin and C - reactive protein on admission, the mortality rates were calculated and compared statistically; the children were divided into four groups with different serum procalcitonin levels as demarcation points： 0. 5 μg/L, 2. 0 μg/L, and 10. 0 μg/L; the same children were divided into three groups with different serum C -reactive protein levels as demarcation points： 10 mg/L and 50 mg/L. Results： The mortality rate of children increased with increase of serum procalcitonin level （P 〈 0. 05 ） ; there was no statistically significant difference in mortality rate between children with high C - reactive protein level and children with normal C - reactive protein level （ P 〉 0. 05 ） . Conclusion ： Serum procalcitonin level of critically ill children is closely correlated with prognosis of the children.

关 键 词：降钙素原 C-反应蛋白 危重病症 预后 

分 类 号：R72[医药卫生—儿科]