SiO_2微球的制备及药物溶出性能研究  

Research on preparation and dissolution properties of silica microspheres

作　　者：葛金龙[1,2] 秦英月[1,2] 王传虎[1,2] 徐婷婷[1] 

机构地区：[1]蚌埠学院应用化学与环境工程系,蚌埠233000 [2]蚌埠学院化工应用技术开发研究所,蚌埠233000

出　　处：《化工新型材料》2014年第2期53-55,共3页New Chemical Materials

基　　金：安徽省教育厅自然科学基金项目(KJ2011B091)

摘　　要：采用模板法制备出分散的球形介孔SiO2微球，以红外光谱仪（FT-IR）、X射线衍射仪（XRD）、热失重差热（TG-DTA）、氮气吸附-脱附（BET）、扫描电镜（SEM）和透射电镜（TEM）等方法对Si02微球的结构及微观形貌进行了表征，结果表明，Si02微球为无定形介孔单分散型，粒径在200-500nm。将制备的si02微球用于盐酸金霉素载体，考察SiO2微球负载盐酸金霉素的溶出度，结果表明：SiO2微球提高了药物的溶出度，在1h左右累计溶出80％，表明制备的介孔SiO2微球可以作为水难溶性药物的优良载体。Monodisperse spherical silica particles were prepared by template-assisted method with cetyltrimethyl ammonium bromide（CTAB）. The phase structure and morphology of were characterized by Fourier trans-form infrared spectrum（FFIR） ,X-ray diffraction（XRD）, thermal analysis and thermal gravimetric analysis （TG-DTA）, N2 sorption-de-sorption isotherms（BET）, scanning electron microscopy（SEM） and transmission electron microscopy（TEM）, respectively. The results showed that silica particles was excellent monodisperse with the carrier specific surface area of 24. 87m^2 / g and particle size in 200-500nm. The dissolution rate of chlortetracycline hydrochloride was significantly improved compared with the raw material from 20% to 80% within an hour. The results showed that the silica particles had lager drug loading capacities, which will be a better drug loading material in future.

关 键 词：SIO2微球 溶出度 盐酸金霉素 

分 类 号：TQ127.2[化学工程—无机化工]