MicroRNA与高血压病  

MicroRNA and hypertension

作　　者：段练[1] 熊兴江[1] 王阶[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中药杂志》2014年第3期397-401,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(90209011)

摘　　要：MicroRNA在高血压病的发生发展中起到重要的作用,包括对肾素血管紧张素醛固酮系统的过激反应,血管内皮的功能紊乱,血管平滑肌的影响,而维持和恢复靶器官中相应miRNA的稳定表达可能成为高血压病治疗的一个新靶点。miRNA的调控过程的阐明和特定miRNA在高血压的靶点的明确将是一项非常有价值,非常激动人心的研究。可能将高血压的治疗方法引领向新的高度。回顾miRNA与高血压病的发病机制,以及miRNA作为生物标志物以及治疗靶点的研究,为今后的研究提供重要借鉴是非常必要的。MicroRNA（miRNA） is involved in virtually all biologic processes, including cellular proliferation, apoptosis, and differentiation. Thus, miRNA deregulation often results in impaired cellular function and disease development, so miRNAs have potential therapeutic relevance. The elucidation of these processes regulated by miRNAs and the identification of novel miRNA targets in the pathogenesis of hypertension is a highly valuable and exciting strategy that may eventually led to the development of novel treatment ap- proaches for hypertension. Several mechanisms have been implicated in the pathogenesis of hypertension ： overactivation of therenin-angiotensin-aldosterone system （ RAAS）, dysfunction of the vascular endothelium, damnification of vascular smooth muscle. To maintain and restore target organ expression of miRNA stable may be a new strategy for treatment of hypertension. The article reviews pathogenesis of miRNA and hypertension, researches of miRNAs as biomarker and therapeutic target, discusses advances in miRNA-based approaches that may be important in treating hypertension.

关 键 词：MIRNA 高血压 发病机制 治疗 

分 类 号：R544.1[医药卫生—心血管疾病]