辣椒碱立方液晶纳米粒的制备及体外评价  

Preparation and in vitro study on diffusion of capsaicin cubosome

作　　者：彭新生[1] 周艳芳[1] 韩珂[2] 覃玲珍[3] 吴传斌[3] 

机构地区：[1]广东医学院药学院,广东东莞523808 [2]广州医科大学第二附属医院,广东广州510260 [3]中山大学药学院,广东广州510006

出　　处：《中国中药杂志》2014年第4期644-647,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81001643;81173002;81202477);广东省及东莞市科技计划项目(2011B031700058;2011108102020)

摘　　要：该文主要探讨辣椒碱立方液晶纳米粒的体外透皮吸收性能,采用改良的Franz扩散池体外透皮实验技术,对辣椒碱立方液晶纳米粒及其软膏剂进行体外透皮扩散实验。实验结果表明立方液晶纳米粒制剂相对于辣椒碱软膏剂而言,无促进药物渗透作用。但立方液晶纳米粒制剂中的辣椒碱在角质层、表皮层与真皮层中的滞留量明显高于软膏剂(P<0.01),立方液晶纳米粒作为皮肤局部给药的载体可提高作用部位的有效药物浓度,皮肤靶向性好。This study was to investigate the permeability and absorbability of capsaicin cubosome across abdominal skin of the SD rats in vitro. Diffusion of capsaicin cubosome and cream was performed with the modified Franz diffusion cell technique. The capsaicin cubosome showed no enhancement of skin permeation within 24 hours. However, the deposition amounts of capsaicin in the rat skin in the cubosome group was markedly higher than those in the commercial cream group （ P 〈 0. 01 ）. Cubosome showed excellent characetristic of skin-targed which could be a good carrier for the local transdermal drug delivery system.

关 键 词：立方液晶纳米粒 辣椒碱 透皮扩散 皮肤靶向 

分 类 号：TQ461[化学工程—制药化工]