黄芩苷-壳寡糖复合物的制备及其表征  

Preparation of baicalin-chitooligosaccharide compound and its characterization

作　　者：蒋艳荣[1,2] 张振海[1] 叶羽苗 严红梅[1] 丁冬梅[1] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学,江苏南京210046 [3]中国药科大学,江苏南京211198

出　　处：《中国中药杂志》2014年第4期648-652,共5页China Journal of Chinese Materia Medica

基　　金：江苏省社会发展科技支撑计划项目(BE2010756);江苏省中医药科技项目(LZ11065)

摘　　要：该文将壳寡糖应用于黄芩苷复合物的制备,以提高药物的体外溶出度,考察复合物的基本性质。采用溶剂法制备黄芩苷壳寡糖复合物,运用差示扫描量热法(DSC)、扫描电镜法(SEM)、X-射线粉末衍射法(XRD)和红外振动光谱(IR)等分析方法对其结构和理化性质进行了分析,并考察其溶出行为。实验结果显示黄芩苷-壳寡糖摩尔比1:1制备的复合物能显著提高黄芩苷的溶出度。DSC和XRD分析结果显示黄芩苷以非晶形态存在,IR结果表明壳寡糖与黄芩苷之间存在相互作用。黄芩苷-壳寡糖复合物能够显著提高药物的体外溶出度。To apply chitooligosaccharide in the preparation of baicalin compound, in order to increase the drug dissolution in vitro, and investigate the basic property of the compound. Baicalin-chitooligosaccharide compound was prepared by using the solvent method. The structure and physieochemical properties of compound were analyzed by using differential scanning calorimetry （ DSC ） , scanning electron microscopy （SEM）, X-ray powder diffraction （XRD） and infrared vibrational spectrum （IR）, and its dissolution behavior was also investigated. The results showed that the compound prepared at baicalin-chitooligosaccharide molar ratio of 1：1 could significantly improve the dissolution of baiealin. The results of DSC and XRD analysis suggested that baicalin may exist in an amorphous state. IR results indicated the interaction between baicalin and chitooligosaccharide. The baicalin-chitooligosaccharide compound could significantly improve dissolution in vitro of drug.

关 键 词：黄芩苷 壳寡糖 复合物 

分 类 号：TQ461[化学工程—制药化工]