2型糖尿病合并乙型肝炎肝硬化患者不同糖化血红蛋白水平的血清细胞因子变化及其临床意义  

Effect and its clinical significance of glycosylated hemoglobin status on serum cytokine levels in patients with type 2 diabetes plus hepatitis B virus related liver cirrhosis

作　　者：陈杰[1] 徐斌[1] 惠威[1] 李雪梅[1] 郭新会[1] 

机构地区：[1]首都医科大学附属北京佑安医院肝病内分泌科,北京100069

出　　处：《中国糖尿病杂志》2014年第2期138-140,共3页Chinese Journal of Diabetes

摘　　要：目的观察T2DM合并乙型肝炎肝硬化(HBLC)患者不同HbA1c水平的血清细胞因子的变化。方法选取T2DM合并HBLC患者65例,根据HbA1c水平分为血糖控制良好组及血糖控制欠佳组,检测两组血清IL-2、IL-4、IL-6、IL-8、IL-10、干扰素γ(INF-γ)及TNF-α水平。结果血糖控制良好组血清细胞因子IL-2、TNF-α[(42.7±20.5)pg/ml、(30.5±20.2)ng/ml]低于血糖控制欠佳组[(58.2±23.8)pg/ml、(43.5±33.7)ng/ml],血糖控制良好组IL-4、IL-6、IL-8水平[(3.2±1.1)、(7.1±3.7)、(58.3±50.8)pg/ml]高于血糖控制欠佳组[(1.1±0.5)、(3.0±1.3)、(35.5±17.6)pg/ml,P<0.05]。血清IL-8、INF-γ水平两组间差异无统计学意义(P>0.05)。结论 T2DM合并HBLC患者血糖控制良好组对比血糖控制欠佳组辅助性T细胞1和2(Th1/Th2)细胞因子差异明显,其意义有待进一步探究。Objective To investigate the effect of HbAlc on serum cytokine levels in T2DM patients combined with HBV-liver cirrhosis. Methods Sixty five T2DM patients with liver cirrhosis were recruited and divided into good contral group （ HbA1 c〉6.5 %, n= 38） and poor contral group （ HbA1c≤6. 5 %, n=27）. The serum levels of IL2,IL-4,IL-6,IL-8,IL-10,INF 7 and TNF-α were tested. Results The serum levels of IL-2 and TNF-α were higher in good control group [（42.7 ± 20.5） pg/m[, （30.5 ± 20.2） ng/ml] than in poor control group [（58.2＋23.8）pg/ml, （43.5＋33.7）ng/ml]. The serum levels of IL4, IL6, IL-8 were lower in good control group [ （ 3.2 ± 1.1）, （ 7.1 ± 3.7）, （ 58. 3 ± 50.8） pg/ml] than in poor control group[（1. 1-0. 5）,（3. 0±1. 3）,（35.5±17.6）pg/ml,P〈0.05]. Conclusion Good control blood glucose status can halance the cytokine network in hepatitis B virus-related cirrhosis patients.

关 键 词：乙型肝炎病毒 肝硬化 糖尿病 2型 细胞因子 

分 类 号：R587.1[医药卫生—内分泌] R512.62[医药卫生—内科学]