后肢去负荷大鼠恢复期股骨矿盐及血清骨钙素的变化  

Changes of Femur Minerals and Serum BGP in Hindlimb Unloaded Rats during Convalescence.

作　　者：万玉民[1] 张曼夫[1] 崔伟[1] 宋锦萍[1] 

机构地区：[1]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2000年第4期298-300,共3页Space Medicine & Medical Engineering

摘　　要：目的观察模拟失重恢复期骨质的变化。方法 7周龄大鼠尾吊 2 1d后分别自由活动 7d和 2 1d并测定骨矿盐含量。结果大鼠尾吊 2 1d后股骨矿盐明显丢失 ,血清骨钙素含量及血磷浓度明显降低 ;大鼠恢复期第 7天矿盐含量和血清骨钙素浓度仍明显低于对照组 ,但血清钙、磷、镁的浓度明显升高 ;恢复期第 2 1天所有指标均恢复至对照水平。结论大鼠后肢去负荷导致的股骨矿盐丢失可在再负荷后逐渐恢复 ,血清骨钙素可监测骨质的恢复状况。Objective To observe bone mass changes during convalescence after simulated weightlessness. Method 7 week old rats were tail suspended for 21 d then reloaded for 7 d and 21 d to recover,and measared serum BGP. Result Tail suspension of rats for 21 d caused significant decrease of serum BGP and phosphorus as well as femur minerals. Serum BGP and femur minerals were still lower than control levels,but serum contents of calcium、phosphorus and magnesium increased significantly after reloading for 7 d.Femur minerals and serum BGP、calcium、phosphorus and magnesium returned to control levels after reloading for 21 d. Conclusion The deficit in femur mineral induled by hindlimb unloacling in rats can be restored by return to normal weight bearing,BGP can be used to monitor the case of its recovery.

关 键 词：失重模拟 后肢去负荷 骨钙素 骨矿质 含量 股骨 大鼠 

分 类 号：R852.22[医药卫生—航空、航天与航海医学]