ADAM33基因S2位点多态性与支气管哮喘易感性关系的Meta分析  

Association between ADAM33 S2 polymorphsim and susceptibility of bronchial asthma:a meta-analysis

作　　者：李宏彬[1] 赵兵 席景砖[1] 

机构地区：[1]新乡医学院公共卫生学院 [2]驻马店市中心医院

出　　处：《现代预防医学》2014年第5期773-776,共4页Modern Preventive Medicine

基　　金：河南省医学科技攻关计划项目(200803073);驻马店市科技局资助项目(20602)

摘　　要：目的综合评价解整合素金属蛋白酶33(A Disintegrin and Metalloproteinase 33,ADAM33)基因S2位点多态性与哮喘易感性的关系。方法制定统一的检索策略,检索Pubmed、Ovid-Medline、Embase、CNKI、维普及万方数据库中有关ADAM33基因多态性与哮喘易感性关系的病例-对照研究,按照纳入和排除标准选择文献提取相关信息,应用Review Manager 5.0软件进行Meta分析。结果纳入10篇合格文献,均满足遗传平衡检验,累计哮喘2 798例和对照4 357例,其中亚洲哮喘患者1 604例,欧美哮喘患者1 194例。Meta分析结果显示,ADAM33基因S2位点显性模型(CC+CG vs.GG)合并OR值为1.56(95%CI:1.01～2.40,P=0.04),按种族分层分析,亚洲哮喘人群OR值为2.15(95%CI:1.00～4.70,P=0.05)。结论 ADAM33基因S2位点多态性与亚洲人发生哮喘的易感性升高有一定相关性。Objective To explore whether the polymorphisms of $2 in ADAM33 （A Disintegrin and Metalloproteinase 33） gene con- tribute to the susceptibility to asthma. Methods According to the same criteria, all the clinical studies related to the polymorphisms of ADAM33 gene and asthma were searched through PubMed, Ovid-Medline, Embase, CNKI, Wanfang and Weipu database. All retrieved articles were screened and evaluated followed by meta-analysis using RevMan 5 software. Results Ten studies were in- eluded based on the selection criteria. In these studies, with 2 798 asthmatic patients and 4 357 controls, 1 604 Asia patients and 1 194 Europe and America patients respectively, were identified and all control group genotype frequencies were consistent with Hardy-Weinberg equilibrium. Meta-analysis revealed the pooled odds ratio of ADAM33 $2 genotype CC＋CG vs.GG was 1.56 （95% CI： 1.01-2.40, P=-O.04）, strati cation by ethnicity indicated the pooled odds in this model in Asia population subgroup was 2.15 （95%CI： 1.00-4.70, P=0.05）. Conclusion This meta-analysis demonstrates that the ADAM33 $2 polymorphism confers suscepti- bility to asthma in Asians.

关 键 词：哮喘 解整合素金属蛋白酶33 基因多态性 META分析 

分 类 号：R195.1[医药卫生—卫生统计学]