AGT基因M235T多态性与原发性高血压靶器官损伤的关系研究  

Study of association of AGT gene M235T polymorphism with target organ damage in primary hypertension patients

作　　者：张红艳[1] 孙雪文[1] 张志涛[2] 

机构地区：[1]河北工程大学医学院,河北邯郸056002 [2]邯郸市中心医院泌尿外二科,河北邯郸056002

出　　处：《现代预防医学》2014年第5期891-893,共3页Modern Preventive Medicine

基　　金：河北省科技厅基金支持;项目名称:邯郸地区汉族人群高血压相关基因多态性与原发性高血压靶器官损伤的关系研究(11276103D-51)

摘　　要：目的探讨AGT基因M235T多态性与原发性高血压靶器官损伤的关系。方法检测高血压肾病组、高血压左室肥厚组和原发性高血压无并发症组患者的AGT基因型频率,统计学分析比较其差异。结果高血压肾病组和高血压左室肥厚组的AGT 235MM型频率与无并发症组差异无统计学意义(P>0.05),高血压肾病组AGT 235MT型和AGT235TT型频率均高于无并发症组,差异有统计学意义(P<0.05),高血压左室肥厚组AGT 235MT型和AGT 235TT型,尤其TT型频率高于无并发症组,差异有统计学意义(P<0.05)。结论高血压肾病和高血压左室肥厚的发生与AGT235MT型和AGT 235TT型有关。AGT 235TT型尤其容易引起高血压左室肥厚。Objective To investigate the association of AGT gene M235T polymorphism with target organ damage in primary hypertension patients. Methods AGT genotypes were detected respectively in primary hypertension with kidney injury group, primary hypertension with left ventricular hypertrophy group and primary hypertension with no complications group. Then statistic analysis was done to compare the difference. Results There were no significant differences about the frequency of AGT 235MM between pri- mary hypertension with kidney injury group, with left ventricular hypertrophy group and with no complications group （P〉0.05）. In primary hypertension with kidney injury group, the frequency of AGT 235MT and AGT 235TY were higher than that in primary hypertension with no cornplications group （P〈0.05）.In primary hypertension with left ventricular hypertrophy group, the frequency of AGT 235MT and AGT 235TY, especially that of AGT 23533＇ were higher than that in primary hypertension with no complications group （P〈0.05）. Conclusion Primary hypertension with kidney injury or with left ventricular hypertrophy have a relation with AGT 235MT and AGT 235TY.Primary hypertension with left ventricular hypertrophy is more frequently occurred in AGT 235TY.

关 键 词：原发性高血压 靶器官损伤 血管紧张素原基因 M235T多态性 

分 类 号：R34[医药卫生—基础医学]