高尿酸血症与冠状动脉疾病及其严重程度的相关性研究  

Correlation Study Between Hyperuricemia and the Severity of Coronary Artery Disease

作　　者：吕江峰[1] 徐凤玲[1] 刘璐[2] 

机构地区：[1]莱芜市人民医院检验科,山东省271100 [2]莱芜市人民医院心内科,山东省271100

出　　处：《中国循环杂志》2014年第2期103-106,共4页Chinese Circulation Journal

摘　　要：目的:评估预测高尿酸血症与冠状动脉疾病及其严重程度的相关性。方法:选取于2009-09至2012-06在我科门诊或住院治疗的经冠状动脉造影证实至少有一支冠状动脉或主要分支管腔狭窄>50%的患者360例,作为冠状动脉疾病组(n=360),将90例冠状动脉管腔无狭窄及60例冠状动脉管腔狭窄≤50%的患者作为对照组(n=150)。结果:所有患者平均年龄为(62.3±12.5)岁,女性患者体重指数及高血压、糖尿病、高脂血症患病率较男性要高,差异具有统计学意义[分别为(30.1±4.5)kg/m2 vs(27.3±3.9)kg/m2,56.9%(165/290)vs 53.6%(118/220),35.9%(104/290)vs 28.2%(62/220)和71.4%(207/290)vs 63.2%(139/220),P均<0.05];而男性血清肌酐和尿酸浓度要显著高于女性[分别为(119.6±69.9)mg/dl vs(107.2±62.1)mg/dl,(475.1±124.8)μmol/L vs(427.2±133.2)μmol/L],差异均有统计学意义(P均<0.01)。冠状动脉疾病组较对照组患者血清尿酸水平显著升高(P<0.05),在所有患者中,高尿酸血症与患病冠状动脉之间具有线性关系,且在男性患者中高尿酸血症与冠状动脉疾病严重程度呈正相关(OR=1.68,P<0.05)。结论:高尿酸血症与冠状动脉疾病及其严重程度相关。Objective： To assess the correlation between hyperuricemia and the severity of coronary artery disease（CAD）. Methods： We retrospectively studied 2 groups of subjects who were treated in our hospital from 2009-09 to 2012- 06 with the mean age of （62.3＋12.5） years. CAD group, n=360 patients with coronary angiography confirmed diagnosis and Control group, n=150, which contained 90 subjects without luminal stenosis and 60 subjects with luminal stenosis 〈50%. The serum levels of creatinine, uric acid and other basic clinical conditions were compared between 2 groups. Results： The prevalence of BMI, hypertension, diabetes mellitus and hyperlipidemia were higher in female than male patients as （30.1±4.5）kg/m2 vs （27.3±3.9）kg/m2, 56.9% （165/290） vs 53.6% （118/220）, 35.9% （104/290） vs 28.2%（62/220） and 71.4% （207/290） vs 63.2%（139/220）, P〈0.05 respectively. While the serum levels of creatinine and uric acid in male were much higher than female as （119.6±69.9）mg/dl vs （107.2±62.1） mg/dl and （475.1±124.8）lamol/L vs（427.2±133.2）pmol/L, both P〈0.01. Compared with Control group, CAD group had obviously increased serum level of uric acid, P〈0.05, The liner association between hyperuricencia and coronary illness existed in all patieuts, and in male patients, hyperuricewia was positively related to CAD severity （OR= 1.68, P〈0.05）. Conclusion： Asymptomatic hyperuricemia was related to CAD severity and it might be a suspicious symptom for CAD patients.

关 键 词：高尿酸血症 冠状动脉疾病 严重程度 

分 类 号：R541[医药卫生—心血管疾病]