慢性鼻-鼻窦炎的组织重塑研究进展  

A review of tissue remodeling in chronic rhino-sinusitis

作　　者：李雪盛[1] 钱进[1] 李厚恩[1] 李进让[1] 

机构地区：[1]海军总医院全军耳鼻咽喉科中心,北京100048

出　　处：《山东大学耳鼻喉眼学报》2014年第1期84-86,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：慢性鼻-鼻窦炎的病理特点是鼻腔及鼻窦黏膜存在持续炎症浸润,依据是否存在鼻息肉,被分为伴息肉及不伴息肉型。现有的研究表明,慢性鼻-鼻窦炎的发生、发展中存在组织重塑,其中TGF-β及基质金属蛋白酶是影响重塑最重要的细胞因子。研究重塑过程中的细胞因子及其作用机制,有助于选择最佳的治疗靶点。未来研究应进一步明确慢性鼻-鼻窦炎组织重塑复杂径路。Chronic rhino-sinusitis is characterized by persistent inflammation of the nasal and paranasal mucosa and is currently classified into two major subgroups on the basis of the absence or presence of nasal polyps. Current studies show that tissue remodeling existed in the chronic rhino-sinusitis developing. Transforming growth factor-beta and ma- trix metalloproteinases are critical factors involved in the remodeling process. To understand which kind of cytokine is involved and how it works will contribute to choose the best therapeutic target. Further study will be focused on the complicated pathway of tissue remodeling in chronic rhino-sinusitis.

关 键 词：组织重塑 慢性鼻-鼻窦炎 转化生长因子-Β 基质金属蛋白酶 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]