自体表皮移植联合窄谱中波紫外线照射治疗稳定期白癜风的疗效观察  

Efficacy of both autologous epidermal grafting and narrow band ultraviolet B radiation on stable vitiligo

作　　者：张敬东[1] 董振邦[1] 潘永正[1] 王飞[1] 周月娥[1] 吴静[1] 

机构地区：[1]南京,东南大学附属中大医院皮肤科,南京210009

出　　处：《中华医学美学美容杂志》2014年第1期30-32,共3页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的探讨自体表皮移植联合窄谱中波紫外线（narrow band ultraviolet B，NB－UVB）照射治疗稳定期白癜风的临床效果。方法对35例稳定期白癜风患者采用负压吸疱自体表皮移植治疗后受皮区给予NB-UVB照射（治疗组），观察受皮区起效时间，3个月后评价受皮区每块皮片的色素恢复面积（治疗前后数码图像对比），并与37例单纯接受负压吸疱自体表皮移植治疗患者的起效时间以及受皮区每块皮片的色素恢复面积对照（对照组）。结果联合治疗组起效时间和痊愈率与对照组相比，差异有统计学意义（P〈O．05）。结论负压吸疱自体表皮移植联合NB-UVB照射治疗白癜风起效时间较快，并能促进移植皮片的色素面积扩展，使受皮区色素恢复均匀，更大程度地提高治疗效果。Objective To evaluate the efficacy of the autologous epidermal grafting combining with NB-UVB radiation on the treatment of stable vitiligo. Methods Autologous epidermal graft ac quired by suction blister under negative pressure were transplanted onto the laser-abraded depigmented areas, then the narrow-band UVB radiation was given after grafting to 35 patients with stable vitiligo. The onset time and the area repigmentation of every epidermal graft 3 months latter were observed （digital image contrasted before and after treatment）. The resuhs were compared with 37 cases only treated with autologous epidermal grafting. Results Both onset time and the cure rate in combined treatment group were statistically significant （P〈0.05） as compared with control group. Conclusions The combination of autologous epidermal grafting with NB-UVB radiation can shorten the onset time of repigmentation and promote generation and extension of the melanin.

关 键 词：白癜风 皮肤移植术 紫外线疗法 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]