血卟啉单甲醚声动力疗法对兔耳增生性瘢痕的疗效  

Effects of HMME-SDT on hypertrophic scar of rabbit ear

作　　者：李卫[1] 费剑峰[2] 李晓峰[2] 曲志伟[2] 毕佳琦[2] 成勇[2] 孟庆刚[2] 

机构地区：[1]哈尔滨医科大学附属第四医院创伤修复中心 [2]哈尔滨市第一医院骨外科

出　　处：《中华医学美学美容杂志》2014年第1期58-61,共4页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：基金项目：黑龙江省卫生厅资助项目（编号：2009-174,2012-690）;黑龙江省科技计划攻关资助项目（编号：GCloc303-4）;哈尔滨市科技创新人才专项资金项目（编号：2012RFXXS066）

摘　　要：目的观察血卟啉单甲醚声动力疗法对兔耳增生性瘢痕（hyperplastic scar，HS）的疗效。方法成年大耳白兔60只，随机分成5组。在声动力治疗第2、4、6、8周分别切取两组瘢痕组织，进行指标检测。结果治疗组可降低成纤维细胞密度、瘢痕增生指数，与模型对照组比较差异有统计学意义（P〈O．05），可降低胶原纤维的面密度，从上皮化后第4周开始与模型组比较差异有统计学意义（P〈O．01）。结论声动力效应能够显著降低兔耳HS，可望为HS治疗提供新的手段。Objective To observe the clinical efficacy of HMME-SDT therapy for the treatment of hypertrophic scar （HS） of rabbit ear. Methods 60 white rabbits were randomly divided into five groups. The model group and HMME-SDT treatment group were used to establish the models of hy pertrophic scar in ears. Results The effect of HMME-SDT on the fibroblastie density in the hyper trophic scarring models was observed in rabbit ears. The HMME-SDT could lower the fibroblastic density, compared with the model group, with significant difference （P（0. 05）. The effect of HMME-SDT on the collagen area density was noted in the hypertrophic scarring models in rabbit ears. The HMME-SDT could lower the collagen area density, compared with the model group, with signifi cant difference from the fourth week of the epithelialization （P^0.0l）. Conclusions HMME is an ef fective sonosensitizer. HMME-SDT can significantly inhibit hypertrophic scar of rabbit ear.

关 键 词：声动力治疗 血卟啉单甲醚 增生性瘢痕 

分 类 号：R622[医药卫生—整形外科]