高敏肌钙蛋白T在慢性心力衰竭患者中的变化及意义  

Changes of serum high sensitivity of troponin T concentration and its clinical significance in chronic heart failure

作　　者：陈东昌[1] 谷颖[1] 鹿克风[1] 

机构地区：[1]山东大学附属省立医院心血管内科,济南250021

出　　处：《山东大学学报（医学版）》2014年第2期69-72,共4页Journal of Shandong University:Health Sciences

基　　金：山东省自然科学基金(y2007c080);山东省卫生厅科研基金(2007HZ067)

摘　　要：目的探讨高敏肌钙蛋白T(hs-cTnT)在慢性心力衰竭(CHF)患者中的变化及其意义。方法选取慢性心力衰竭患者147例(心衰组),依据心功能分级将其分为4个亚组;同时选取健康查体者30例(对照组)。空腹采血检测血清hs-cTnT及血浆N末端脑钠肽(NT-proBNP)浓度,并行超声心动图检查。结果①心衰组较对照组hs-cTnT浓度显著升高(P<0.05);心衰各亚组间hs-cTnT差异均有统计学意义(P均<0.05),且随心功能分级增加而升高(P<0.05);心衰亚组Ⅰ组较对照组hs-cTnT浓度升高(P<0.05)。心衰组与对照组超声心动图参数、NT-proBNP浓度差异有统计学意义(P<0.05);心衰各亚组之间超声心动图参数、NT-proBNP浓度差异有统计学意义(P<0.05)。②心衰组Log hs-cTnT与Log NT-proBNP、LAd、LVEDd呈正相关(r分别为:0.680,0.345,0.326,P均<0.05),与LVEF呈负相关(r=-0.551,P<0.05)。结论慢性心力衰竭患者无论有无心衰症状,血清hs-cTnT均升高,并与心衰程度及NT-proBNP呈正相关,hs-cTnT能较好反映慢性心衰患者的心功能状态。Objective To investigate the changes and clinical significance of the concentration of serum high sensitivity of cardiac troponin T （hs-cTnT） in chronic heart failure （CHF）. Methods A total of 147 patients with chronic heart failure were enrolled in the chronic heart failure group （ CHF group）, which was divided into 4 subgroups, and 30 healthy objectives were controls. The cardiac function of the patients was evaluated according to the standard of Ameri- can New York Heart Association （NYHA）. The blood samples of all patients and controls were collected, the concen- trations of serum hs-cTnT and NT-proBNP were detected, and echocardiography was performed. Results ① The con- centration of serum hs-cTnT of the CHF group were higher than that of the control group （ P 〈 0.05 ）. The concentra- tions of serum hs-cTnT were obviously different among the subgroups （P 〈 0.05 ）, and the worse the cardiac function was, the higher the serum hs-cTnT was. The echocardiographic parameters and NT-proBNP concentration of the CHF group and control group were statistically different （ P 〈 0.05 ）. The echocardiographic parameters and NT-proBNP con- centration of the subgroups of the CHF group were statistically different （ P 〈 0.05 ）.② Serum hs-cTnT of the CHF group was positively correlated with NT-proBNP, LAd, and LVEDd （ r = 0. 680, 0. 345 and 0. 326, P 〈 0.05 ）, and negatively correlated with LVEF （ r = - 0. 551, P 〈 0.05 ）. Conclusion The concentration of the serum hs-cTnT is elevated and positively correlated to the severity of heart failure and concentration of plasma NT-proBNP, which can reflect patients＇ cardiac function.

关 键 词：高敏肌钙蛋白T N末端脑钠肽 心功能 

分 类 号：R541[医药卫生—心血管疾病]