低剂量染石英尘大鼠支气管肺泡冲洗液磷脂谱变化的研究  

STUDY OF PHOSPHOLIPID SPECTRUM IN RAT BRONCHOALVEOLAR LAVAGE FLUID AFTER INSTILLING LOW DOSE OF QUARTZ DUST

作　　者：田琳[1] 郭鼐 姚汝琳[1] 杨青[1] 裴秋玲[1] 

机构地区：[1]山西医学院卫生系,太原市新建南路10号030001

出　　处：《工业卫生与职业病》1991年第1期1-4,共4页Industrial Health and Occupational Diseases

摘　　要：本文报道了给大鼠气管注入低剂量石英尘后其BALF中总磷脂、DPPC、PI、PS、Sph和LPC含量的动态变化。实验分为对照组和石英组,分别于染尘后7天、15天、60天和120天分组剖检。结果表明,总磷脂、DPPC染尘后7～120天一直呈上升趋势,Sph、PI也明显增加,PS、LPC无明显改变。并对结果进行了讨论。Changes of the contents of total phospholipid, DPPC, PI, PS, Sph, and LPC in rats' bronchoalveolar lavage fluid (BALF) after instilling intra-tracheally low doses of quartz were observed.The rats were divided into 2 groups: control and quartz ones. All rats were killed at intervals of 7, 15, 60 and 120 days after instillation. The results indicated that there was an increasing tendency of the contents of total phospholipid and DPPC during 7-120 days after instillation. The contents of PI and Sph were significantly higher than those of the control group. No significant increase in contents of PS and LPC was observed. The results were discussed.

关 键 词：石英 支气管肺泡 冲洗液 磷脂 

分 类 号：R598.2[医药卫生—内科学]