妊娠期妇女亚临床甲状腺功能减退对后代智力发育影响的Meta分析  

A meta-analysis about the impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism

作　　者：徐晓艺[1] 谢敏[1] 李铮[1] 李竞[1] 

机构地区：[1]武汉大学人民医院内分泌科,430060

出　　处：《临床内科杂志》2014年第1期46-48,共3页Journal of Clinical Internal Medicine

摘　　要：目的 探讨妊娠期妇女亚临床甲状腺功能减退（简称亚临床甲减）对后代智力发育的影响.方法 计算机检索关于妊娠期妇女亚临床甲减对后代智力发育影响的随机对照研究.在严格质量评价的基础上,应用RevMan 5.1软件进行Meta分析.结果 纳入的文献共8篇,包含731个研究对象.Meta分析结果显示,妊娠期妇女亚临床甲减对后代智力发育的影响与对照组相比差异有统计学意义（P＜0.05）;妊娠期妇女亚临床甲减经左旋甲状腺素（LT4）干预后对后代智力发育的影响与对照组比较,差异无统计学意义（P＞0.05）.结论 妊娠期妇女亚临床甲减对后代的智力发育会造成不良影响,经积极治疗后可减小这种危害.Objective To evaluate the impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism. Methods Computer retrieve the random control studys about the impact on the mental development of the offspring by pregnant women with subclinical hypothy- roidism. Data analyses were performed with the RevMan 5.1 software, based on the strict quality evalua- tion. Results Eight studies comprising 731 subjects were analyzed. Meta-analyses showed that the impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism had statisti- cal significance, when compared with the control group （P 〈 0.05 ）. The impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism treated with LT4 had no significance, when compared with the control group （ P 〉 0. 05 ）. Conclusion Gestational women with subclinical hypothyroidism will adversely affect the mental development of future generations, but the harm can be reduced after active treatment.

关 键 词：妊娠期 亚临床甲减 后代智力发育 LT4干预 META分析 

分 类 号：R581.2[医药卫生—内分泌]