国产与进口单唾液酸四己糖神经节苷脂治疗小儿脑性瘫痪的疗效观察  

Clinical Observation on Therapeutic Effect of Domestic and Imported Monosialotetrahexosylganglioside in the Treatment of Children with Cerebral Palsy

作　　者：关芳娟 高姗[1] 关丽君[1] 

机构地区：[1]沈阳市儿童医院,沈阳110032

出　　处：《中国药师》2014年第1期123-125,共3页China Pharmacist

摘　　要：目的:观察国产与进口单唾液酸四己糖神经节苷脂(GM1)治疗小儿脑性瘫痪的临床疗效。方法:83例脑瘫惠儿分为国产组(42例)和进口组(41例),两组患儿均采用常规训练和治疗,同时分别给予国产和进口单唾液酸四己糖神经节苷脂,比较两组疗效和安全性,结果:治疗后,国产组和进口组的总有效率、粗大运动功能评分(GMFM)和精细运动功能评分(FMFM)及不良反应发生率差异均无统计学意义(P>0.05)。结论:凶产与进口单唾液酸四己糖神经节苷脂治疗小儿脑性瘫痪有相似的临床疗效。Objective： To observe the therapeutic effect of domestic and imported monosialotetmhexosylganglioside （GM1） in the treatment of children with cerebral palsy. Methods： Totally 83 children patients with cerebral palsy were random｜y divided into two groups： the domestic group （n =42） and imported group （n = 41 ） combined with conventional training and drugs. The cases in the domestic group were treated by the domestic GM1, while the cases in the imported group were given by the imported GM1. The thera- peutic effects were evaluated. Results： There was no significmlt diffefrence in the total effective rate, GMFM and FMFM scale and side effect rate after the treatment by the domestic and imported GM1 （P 〉 0.05 ）. Conclusion： Domestic and imported GM 1 have similar therapeutic effect in the treatment of children with cerebral palsy.

关 键 词：小儿脑性瘫痪 单唾液酸四己糖神经节苷脂 疗效 

分 类 号：R971.7[医药卫生—药品]