正交试验法优选胃乐舒颗粒的醇提工艺  

Optimization of Ethanol Extraction Process for Weileshu Granules by Orthogonal Tests

作　　者：张松亮[1] 顾腾飞 于天杰[1] 

机构地区：[1]解放军第152中心医院,河南平顶山467000

出　　处：《中国药师》2014年第1期165-167,共3页China Pharmacist

摘　　要：目的:优选胃乐舒颗粒药材中醇溶性成分的提取工艺。方法:以延胡索乙素、木香烃内酯、去氢木香内酯提取量和浸膏收率为评价指标。采用正交试验设计确定最佳醇提工艺。结果:胃乐舒颗粒最佳提取工艺为:加6倍量的80%乙醇,加热回流3次,每次1 h。结论:该提取工艺高效、稳定,适用于大生产。Objective： To optimize the ethanol extraction process for Weileshu granules. Methods： With the extract yield and the amount of tetrahydropalmatine, costunolide and dchydrocostus lactone as the indices, the extraction conditions were optimized by or- thogonal tests. Results： The best extraction process was the follows： refluxing 3 times with lh each and in 6-fold amount of 80% alco- hol. Conclusion： The process is efficient, stable and applicable in the industrial production.

关 键 词：胃乐舒颗粒 延胡索乙素 木香烃内酯 去氢木香内酯 正交试验 

分 类 号：R284.2[医药卫生—中药学]