透明质酸钠与几丁糖预防甲状腺术后粘连效果比较分析  

Effect Comparative Analysis of Sodium Hyaluronate and Chitosan in the Prevention of Thyroid Postoperative Adhesion

作　　者：沈强[1] 王全[1] 杨俊杰[1] 

机构地区：[1]嘉兴市嘉善县第一人民医院外一科,浙江嘉兴314100

出　　处：《中国药师》2014年第2期266-268,共3页China Pharmacist

摘　　要：目的：探讨透明质酸钠和几丁糖分别用于甲状腺术后粘连的治疗效果。方法：甲状腺手术患者84例根据入院时间分为甲、乙两组各42例，为防止术后粘连，甲组采用透明质酸钠3～6ml均匀涂抹于创面、颈前肌群深面和颈阔肌深面，乙组采用3～6ml均匀涂抹于上述位置。术后5～7d拆线出院，3个月后评估预防粘连效果，比较两组临床疗效及不良反应发生情况。结果：甲组粘连率为14．3％（6／42），略高于乙组7．1％（3／42），但差异无统计学意义（P〉0．05）；两组患者均无渗血和过敏等不良反应，仅甲组出现2例（4．8％）轻微感染者，两组不良反应发生率差异无统计学意义（P〉0．05）。结论：透明质酸钠和几丁糖均有预防甲状腺术后粘连的效果，两者预防有效率和不良反应基本相当。Objective： To investigate and compare the effect of sodium hyaluronate and chitosan in the prevention of thyroid post-operative adhesion. Methods： Totally 84 patients with thyroid operation in our hospital from August 2012 to August 2013 were select- ed, and according to the admission time, the patients were respectively divided into group A and B with 42 cases each. In order to prevent postoperative adhesion, group A was treated with sodium hyaluronate, and group B was treated with chitosan. The clinical curative effect of the two groups was compared. Results： The adhesion rate in group A was 14.3% （6/42）, which was higher than that in group B （ 3/42 7.1% ）, while the difference was not statistically significant （ P 〉 0.05 ）. All the patients showed no bleeding, allergies and other adverse reactions, only in group A, 2 mild infection （4.8%） occurred. The adverse reactions in the two groups were without significant difference （ P 〉 0.05 ）. Conclusion ： Sodium hyaluronate and chitosan both have the preventive effect on thyroid postoperative adhesion with similar efficiency and adverse reactions.

关 键 词：甲状腺术 透明质酸钠 几丁糖 粘连 

分 类 号：R653[医药卫生—外科学]