HPLC法测定厄贝沙坦片含量的不确定度分析  

Analysis of Measurement Uncertainty in Determination of Irbesartan Tablets by HPLC

作　　者：成源[1] 李晓雯[1] 

机构地区：[1]扬子江药业集团北京海燕药业有限公司,北京102206

出　　处：《中国药师》2014年第2期326-328,共3页China Pharmacist

摘　　要：目的:对HPLC法测定厄贝沙坦片含量的不确定度分析,找出影响不确定度的因素。方法:根据含量测定不确定度的数学模型,对各个不确定度分量进行计算。结果:本法测量扩展不确定度为2.4%。结论:本法的测量不确定度主要由测量方法所引入。Objective： To find out the impacting factors in uncertainty by analyzing the measurement uncertainty in the determination of irbesartan tablets by HPLC and provide the evidence for the measurement evaluation. Methods： A mathematic model for calculating uncertainty was established, and every component in the uncertainty was assessed. Results：The expanded standard uncertainty for the HPLC determination was 2.4%. Conclusion：The measurement uncertainty of the experiment is mainly caused by the measuring method.

关 键 词：测量不确定度 厄贝沙坦片 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学]