不同周龄Balb/c小鼠脏器质量及其变化趋势分析  

Measurement and Change Trend Analysis of Organ Weights in Balb/c Mice of Different Ages

作　　者：刘福剀 关雪[2] 杨昕蕾[1] 陈剑锋[2] 杨永良[2] 梁重阳[3] 

机构地区：[1]哈尔滨医科大学附属第一医院实验动物中心,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第二医院实验动物中心,黑龙江哈尔滨150086 [3]吉林大学再生医学科学研究所,吉林长春130021

出　　处：《现代生物医学进展》2014年第3期421-424,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年基金项目(81202446)

摘　　要：目的:测定不同周龄Balb/c小鼠主要脏器质量、脏器系数,并进行比较。方法:取120只3周龄、5周龄、7周龄的Balb/c小鼠,雌雄各半,精确测量小鼠体重和主要脏器质量,计算脏器系数。结果:①雌性与雄性Balb/c小鼠脏器质量相比较:3周龄时肝、脾有显著差异(P<0.05);5周龄时肝有非常显著差异(P<0.01),脾、肺有显著差异(P<0.05);7周龄时肝、肺及双肾有非常显著差异(P<0.01),心、脾有显著差异(P<0.05)。②雌性与雄性Balb/c小鼠脏器系数相比较:3周龄时肝、脾有显著差异(P<0.05);5周龄时肝、脾有非常显著差异(P<0.01),膀胱有显著差异(P<0.05);7周龄时肺、双肾有非常显著差异(P<0.01),脾、膀胱有显著差异(P<0.05)。结论:随着周龄的增长,Balb/c雌、雄性小鼠之间,存在差异的脏器也在增多。Objective： To measure and compare the weight of main organs and the organ coefficient between male and female Balb/c mice of different ages. Methods： 20 male and 20 female Balb/c mice at the ages of 3 weeks, 5 weeks and 7 weeks （total 120 mice） were used for the measurement of weight of main organs and organ coefficient. Results： 1. Comparing the organ weight between female and male Balb/c mice, significant difference （P〈0.05） for liver or spleen of mice of 3 weeks old, distinct significant differences （P〈0.01） for liver and significant differences （P〈0.05） for spleen or lungs of mice of 5 weeks old, distinct significant differences （P〈0.01） for liver, lungs or double kidneys and significant differences （P〈0.05） for heart or spleen of mice of 7 weeks old Balb/c were observed in the study. 2. Comparing the organ coefficient between female and male Balb/c mice, significant differences （P〈0.05） for liver or spleen of mice of 3 weeks old, distinct significant differences （P〈0.01） for liver or spleen and significant differences （P〈0.05） for bladder of mice of 5 weeks old; distinct significant differences （P〈0.01） for lungs or double kidneys and significant differences （P〈0.05） for spleen or bladder of mice of 7 weeks old were observed in the study. Conclusion： As the growth of Balb/c mice, the difference of organs between female and male mice is increasingly notable.

关 键 词：BALB C小鼠 脏器质量 脏器系数 

分 类 号：Q953[生物学—动物学]