基础卵泡刺激素水平对IVF/ICSI-ET超排卵周期卵巢反应的预测价值  

Prediction Values of bFSH on the Response to Ovary in the IVF/ICSI-ET Super Ovulation Cycle

作　　者：张晓莉[1,2] 姚元庆[1] 彭红梅[1] 王黎娜[2] 郭晓东[3] 王辉[4] 

机构地区：[1]解放军总医院妇产科,北京100853 [2]武警总医院妇产科,北京100049 [3]解放军第302医院,北京100039 [4]北京石景山医院,北京100043

出　　处：《现代生物医学进展》2014年第4期643-645,662,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年科学基金项目(30901795)

摘　　要：目的:基础卵泡刺激素(bFSH)可以刺激精子生成和促进卵子成熟,是人体内重要的激素之一。本研究针对体外受精(IVF)周期bFSH水平的变化情况,探讨bFSH对卵巢反应的预测价值,为临床研究提供理论基础。方法:回顾性分析2012年1月-2012年12月在我院生殖医学中心接受体外受精-胚胎移植(IVF-ET)治疗的154例患者的临床资料,根据基础卵泡刺激素水平分为A组(bFSH≥10 IU/L)、B组(8≤bFSH≤10 IU/L)和C组(bFSH<8 IU/L)。对比分析三组对象的年龄、基础窦卵泡数(bAFC)、黄体生成素(LH)含量、FSH/LH值、促性腺激素(Gn)的用量、使用时间、受精率及临床妊娠率等。结果:三组患者的年龄、bAFC及FSH/LH相比较,差异具有统计学意义(P<0.05);三组的Gn用量和时间、获卵数及妊娠率比较,差异显著且具有统计学意义(P<0.05);三组基础LH值及超排卵周期受精率无显著差异(P>0.05)。结论:基础卵泡刺激素(bFSH)对体外受精女性的卵巢储备功能具有一定的预测价值,bFSH水平的高低可作为预测女性不孕患者超排卵周期卵巢反应性的一项重要指标,值得临床推广和应用。Objective： The basic follicle-stimulating hormone（bFSH） is one of the most important hormones in human body which could stimulate the production and maturity of sperm. This study aims to exploring the predictive value for ovarian response by means of observing the changes ofbFSH levels during the in vitro fertilization （IVF） cycle so as to provide a theoretical basis for clinical research. Methods： A retrospective analysis was performed on the clinical data of 154 patients who were accepted the IVF-ET at the center of reproductive medicine in our hospital fxom January 2012 to December 2012. According to the bFSH levels, the selected patients were divided into three groups, namely, the group A （bFSH~〉 10 1U/L）; group B （8~〈bFSH~〈 10 IU/L） and group C （bFSH〈8 IU/L）. Then the age, the bAFC values, the time and dose of Gn, the rate of fertilization and pregnancy in three groups were compared and evaluated. Results： There were statistically significant differences about the age, the bAFC values, the rate of FSH and LH, the time and dose of Gn, the numbers of ovum and the rate of pregnancy （P〈0.05）. But there was no statistically significant difference about the values of LH and the rate of fertilization in three groups （P〉0.05）. Conclusions： It is indicated that the values of bFSH could predict the functions of women＇s ovary for those who were taken the in vitro fertilization and the levels ofbFSH might become an essential item in the future for the clinical to detect the ovarian reactions of the infertile females during the super ovulation cycles.

关 键 词：泡刺激素 体外受精 卵巢反应 促排卵 

分 类 号：R711.6[医药卫生—妇产科学]