石油作业习惯性流产女性细胞遗传毒性研究  

Study on Genetic Toxicity of Habitual Abortion Women in Petroleum Operations

作　　者：慕明涛[1] 霍满鹏[1] 张静[1] 刘俊俊[1] 蒲力群[1] 

机构地区：[1]延安大学医学院医学遗传学与细胞生物学教研室,陕西延安716000

出　　处：《现代生物医学进展》2014年第4期709-711,共3页Progress in Modern Biomedicine

基　　金：延安大学自然科学研究计划项目(YD2011-04)

摘　　要：目的:研究石油作业环境对女性习惯性流产的遗传毒性。方法:随机选择习惯性流产的石油作业女性38人和正常的育龄女性20人,检测其外周血淋巴细胞姐妹染色单体互换,记数SCE发生率。结果:观察组的外周血淋巴细胞SCE发生率为8.81±0.35,明显高于对照组(P<0.05)。结论:SCE的发生可作为石油作业习惯性流产女性染色体结构稳定性的检测指标。石油作业环境对女性生育具有遗传毒性。Objective： To Analyze of Genetic Toxicity in peripheral blood lymphocytes among habitual abortion women in the petroleum operations. Methods： 38 women with habitual abortion and 20 normal women with childbearing age were selected randomly as observation group and control group respectively. The peripheral blood lymphocytes from them were cultivated and detected by SCE test method, and the frequency of them was counted. Results： The frequency of SCE was 8.81＋ 0.35, and its frequency in observation group was higher than that in control group （P 〈0.05）. Conclusion： The incidence of SCE can be used as the detective index of chromosome＇s structural stability of women and genetic toxicity, and is shown in female fertility with habitual abortions who are exposed to the environment in petroleum operations.

关 键 词：习惯性流产 姐妹染色单体互换 DNA损伤 

分 类 号：R714.21[医药卫生—妇产科学] R394.6[医药卫生—临床医学]