免疫耐受在胰岛移植中的研究进展  

The Research Progress of Immunological Tolerance in Islet Transplantation

作　　者：高庆坤[1] 孔娜[1] 宋春芳[1] 周毅[1] 

机构地区：[1]哈尔滨医科大学附属第一医院甲状腺乳腺外科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2014年第4期795-797,782,共4页Progress in Modern Biomedicine

摘　　要：胰岛移植已经被公认为治疗胰岛素依赖型糖尿病(IMDD)的有效手段,而现如今胰岛移植的最大障碍是移植排斥反应。目前控制胰岛移植的免疫抑制治疗因其对胰岛细胞的毒性作用及长期应用带来的全身并发症而无法在临床推广,诱导移植术后受体的免疫耐受是防止排斥反应的最理想方法。本文综述了诱导免疫耐受的途径及胰岛移植的最新实验进展。随着研究的深入和免疫学的发展,相信在未来的胰岛移植治疗糖尿病领域,移植排斥现象将能得到高效可靠的解决。： Islet transplantation is an effective treatment method of insulin dependent diabetes mellitus （ IMDD ）. Transplant rejection is the biggest obstacle of Islet transplantation. At present, immunosuppressive therapy popularize in the clinical because of the islet cell toxicity and systemic complications caused by long-term application.Inducing transplantation receptor immunological tolerance is the most ideal method to prevent rejection. This paper evaluates recent progress in promoting long-term survival and tolerance in animal models of islet transplantation. With the deepening of the research and the development of immunology, we believed islet transplantation for diabetes, graft rejection phenomenon will be soluted.

关 键 词：糖尿病 胰岛移植 免疫耐受 

分 类 号：R657.5[医药卫生—外科学]