白癜风患者合并自身免疫性甲状腺疾病的临床分析  

Clinical analysis of vitiligo patients combined with autoimmune thyroid diseases

作　　者：张久丹 李洁[1] 许一新[1] 陈晔[1] 柏晓勇[1] 刘隽[1] 卢斌[1] 王扬天[1] 王坚[1] 

机构地区：[1]南方医科大学附属南京军区南京总医院内分泌病科,江苏省210002

出　　处：《江苏医药》2014年第3期294-296,共3页Jiangsu Medical Journal

摘　　要：目的探讨成年白癜风患者合并自身免疫性甲状腺疾病的发生率及其影响因素。方法检测60例成年白癜风患者(A组)和60例正常人(B组)的甲状腺功能及甲状腺相关抗体水平,并行甲状腺超声检查。比较两组血清甲状腺抗体的阳性率及自身免疫性甲状腺疾病发生率。结果与B组比较,A组患者血清中甲状腺过氧化物酶抗体(TPOAb)阳性率(8.3%vs.1.7%)及合并自身免疫性甲状腺疾病比例(8.3%vs.0)均增加(P<0.05);血清TPOAb水平与白癜风患者的性别及病程有明显相关性,与发病年龄、白癜风类型及活动性无明显关联性。结论白癜风患者应定期监测甲状腺功能及甲状腺相关抗体,以期尽早发现甲状腺功能异常。Objective To analyze the incidence and related factors of vitiligo patients combined with autoimmune thyroid diseases. Methods The thyroid functions and thyroid-related antibodies were examined in 60 adults with vitiligo （group A） and 60 healthy subjects （group B）. Ultrasonic testing of the thyroid was performed as well. Results The positive rate of antithyroperoxidase antibody（TPOAb） and the incidence of autoimmune thyroid diseases were higher in group A than those in group B（8. 3% vs. 1.7% and 8. 3% vs. 0） （P〈0. 05）. Serum level of TPOAb was closely related to the duration of disease and sex（P〈0. 05） ,which was not significantly associated with age, type and activity of vitiligo. Conclusion It is necessary to regularly examine the thyroid functions and thyroid-related antibodies in the patients with vitiligo in order to early finding abnormal thyroid functions.

关 键 词：白癜风 甲状腺功能 自身免疫性甲状腺疾病 抗甲状腺抗体 

分 类 号：R581[医药卫生—内分泌]