甲状腺机能亢进症患者血清尿酸水平的变化  

Changes of serum uric acid concentration in patients with hyperthyroidism

作　　者：曹雯[1,2] 郑仁东[1,2] 吕伶[3] 夏萍[1,2] 刘超[1,2] 

机构地区：[1]中国中医科学院江苏分院 [2]南京中医药大学附属中西医结合医院内分泌代谢病院区,江苏省210028 [3]南京医科大学附属南京市妇幼保健院

出　　处：《江苏医药》2014年第3期299-300,共2页Jiangsu Medical Journal

基　　金：江苏省科技计划项目(BM2012064)

摘　　要：目的探讨甲状腺机能亢进症(甲亢)患者血清尿酸水平的变化特点。方法检测60例甲亢患者(A组)、50例亚临床甲亢患者(B组)和110例健康人(C组)血清尿酸水平。结果与C组比较,A组、B组血清尿酸水平升高(P<0.01)。A组血清尿酸水平与血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)呈正相关,与促甲状腺激素(TSH)呈负相关。B组、C组尿酸水平与FT3、FT4、TSH无相关性。结论甲亢患者尿酸水平升高是心血管疾病的又一高危因素。伴有高尿酸血症的甲亢患者,在积极治疗甲亢的同时,应该通过多种途径对高尿酸水平进行干预。Objective To analyze the changes of serum uric acid concentration in patients with hyperthyroidism. Methods Serum concentrations of uric acid were detected and compared in 60 patients with hyperthyroidism（group A）,50 patients with subclinical hyperthyroidism（group B） and 110 healthy persons（group C）. Results Serum level of uric acid was higher in groups of A and B than that in group C（P〈0. 01）. Serum level of uric acid in group A was positively correlated with the levels of serum free thyroxine （FT4） and free triiodothyronine （FT3）, but negatively correlated to serum level thyroid stimulating hormone（TSH）. However the uric acid concentrations in groups of B and C were not significantly correlated with serum concentrations of FT3, FT4 and TSH, Conclusion High serum level of uric acid may be another risk factor for cardiovascular disease. More intervention should be considered in the patients with hyperthyroidism combined with elevated serum uric acid.

关 键 词：甲状腺机能亢进症 高尿酸血症 甲状腺激素 

分 类 号：R581[医药卫生—内分泌]