白芍总苷联合阿维A治疗斑块型银屑病35例疗效观察  

Observation of Efficacy of Total Glucosides of Paeon Combined with Acitretin in the Treatment of Psoriasis Plaque

作　　者：江浩波[1] 石文植[1] 孙志平[1] 张淑芳[1] 刘平花[1] 陈海针[1] 

机构地区：[1]中山大学附属东华医院皮肤科,广东东莞523110

出　　处：《中国皮肤性病学杂志》2014年第3期325-326,328,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的观察白芍总苷联合阿维A治疗斑块型银屑病的临床疗效。方法将69例斑块型银屑病患者随机分为两组,治疗组35例,口服白芍总苷联合阿维A;对照组34例,仅予口服阿维A治疗。两组患者的疗程均为12周。结果治疗第6周和12周时治疗组患者的PASI评分分别为(8.91±3.16)、(3.38±1.74),对照组为(11.76±3.43)、(5.07±2.02),差异均有统计学意义(P<0.05);而且治疗12周后治疗组有效率(85.71%)显著高于对照组(64.71%),差异均有统计学意义(P均<0.05)。另外,两组患者不良反应发生率均较低和轻微。结论白芍总苷联合阿维A治疗斑块型银屑病疗效较好,安全性高。Objective To observe the efficacy of total glucosides of paeon combined with acitretin in the treatment of psoriasis plaque. Methods 69 cases of psoriasis plaque were divided into two groups and treated for 12 weeks. The treatment group （ n = 35） was treated with total glucosides of paeon combine with acitretin, and the control group（ n = 34） was treated with acitretin only. Results After 6 weeks andl2 weeks treatment, the PASI scores were respectively （ 8.91 ~ 3.16） and （3.38 ＋ 1.74） in treatment group, but （ 11.76 ＋ 3.43 ） and （5.07 ＋ 2.02） in control group, showing significant difference （ P 〈 O. 05 ）. After 12 weeks, the efficiency of treatment group was 85.71%, which was significantly higher than that of control group （ 64.71% , P 〈 0. 05 ）, and low frequency of the adverse reactions was. Observed. Conclusion The combination of total glucosides of paeon with acitretin is an effective and safe option for psoriasis plaque.

关 键 词：白芍总苷 阿维A 银屑病 斑块型 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]