高脂饮食对幼年小鼠骨量影响的研究  

Effect of high fat diet on bone mass in young mice

作　　者：舒磊[1] 李明泉[1] 王晓霞[1] 王昕怡[1] 赵明[1] 

机构地区：[1]南京军区南京总医院于部内分泌科,210002

出　　处：《中华内分泌代谢杂志》2014年第2期150-152,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：用正常饮食或高脂饮食处理C57BL／6J8周龄幼年雄性小鼠，4周后观察小鼠骨量、破骨细胞数目和活性，骨髓问充质细胞向成骨细胞分化能力以及调脂基因表达水平的变化。与正常饮食处理组相比，高脂饮食处理后小鼠股骨骨量降低，破骨细胞数增加、活性增强，调脂基因表达水平上调，但骨髓问充质细胞向成骨细胞分化能力无明显改变。高脂饮食诱导的幼年小鼠骨量减少主要是由于破骨细胞活性增强和骨吸收增加所致。Eight-weeks old C57BL/6J male mice were treated with normal or high fat diet for 4 weeks, and then bone mass, number and activity of osteoclasts, differentiation of osteoblasts from bone marrow mesenchymal cells and the change in lipid genes expression were studied. Compared with the normal diet treated group, bone mass of femur from high fat diet treated animal was decreased, but there were increased number and activity of osteoclasts and raised lipid genes expression levels. Besides, no obvious change was found in differentiation of osteoblasts from bone marrow mesenchymal cells. The loss of bone mass induced with high fat diet in young mice was mainly due to increased activity of osteoclasts and bone resorption.

关 键 词：破骨细胞 成骨细胞 骨吸收 PPARΓ 

分 类 号：R723.14[医药卫生—儿科]