实时三维超声斑点追踪技术评价甲状腺功能减退患者左室整体收缩功能  

Assessment of Left Ventricular Global Systolic Function Using Real-time Three-dimensional Speckle-tracking Echocardiography in Patients with Hypothyroidism

作　　者：谢秋[1] 李慧[1] 李晨[1] 白文娟[1] 李春梅[1] 彭瑛[1] 饶莉[1] 

机构地区：[1]四川大学华西医院心血管内科,成都610041

出　　处：《生物医学工程学杂志》2014年第1期58-63,共6页Journal of Biomedical Engineering

基　　金：四川省科技支撑项目资助(2012SZ0028);成都市科技计划项目资助(10GGYB076SF-023)

摘　　要：应用实时三维斑点追踪显像(RT3D-STI)技术探讨甲状腺激素减低对左室整体收缩功能的影响。本研究纳入30例甲状腺功能减退患者与40例健康志愿者,应用RT3D-STI分析左室整体纵向应变(GLS)、环周应变(GCS)、径向应变(GRS)、面积应变(GAS)。甲减组和健康对照组GLS[(-18.93±3.89)vs.(-21.44±1.99),P<0.01]、GRS[(51.13±11.95)vs.(56.10±5.76),P<0.05]和GAS[(-31.63±5.38)vs.(-34.40±2.32),P<0.05]差异有统计学意义,GCS[(-17.75±1.92)vs.(-17.03±3.45,P>0.05]差异无统计学意义。回归分析发现,GLS值与TSH(b=-0.69,P<0.01)、FT3(b=0.71,P<0.01)水平存在直线回归关系;GRS值(b=2.98,P<0.05)、GAS(b=3.11,P<0.05)与FT3水平存在直线回归关系。结果说明:甲减患者的左室整体收缩运动减低,其中以长轴、向心运动损害为著,随着TSH水平的升高和FT3水平的降低损害加深。The present study aimed to investigate the impact of hypothyroidism on left ventricular systolic function using real time three-dimensional speckle tracking imaging （RT3D-STI）. Thirty hypothyroidism patients and forty healthy volunteers were recruited and received RT3D-STI measurement of global longitudinal strain （GLS）, global circumferential strain （GCS）, global radial strain （GRS）, and global area strain （GAS）. A comparison of differences between the hypothyroidism patients and those in the heahhy group was carried out and we obtained the results as followings. The values of GLS were （-18.93±3.89） vs. （-21.44±1.99）, with P〈0.01, GRS were （51.134±11.95） vs. （56.10±5.76）, with P〈0.0; and GAS were （-31.63±5.38） vs.（-34.40±2.32）, with P〈0.01, i.e. they were lower in hypothyroidism group than those in the health group. While GCS were （ --17.75±1.92） vs. （-17.03±3.45）, with P〉0.05, which were not significantly different between the two groups. In linear regression, GLS showed significant correlation with both TSH （b=-0.69, P〈0.01） and FT3（b=0.71, P〈0.01）. Meanwhile, the GRS （b=2.98, P〈0.05） and GAS （b=3.11, P〈0.05） linearly correlated with FT3 level. In conclusion, the present study shows that the global longitudinal and radial moves of left ventricular are weaker in pa tients with hypothyroidism than healthy controls. And the impairment of left ventricular function would aggravate as FSH rises or FT3 declines.

关 键 词：甲状腺功能减退症 实时三维斑点追踪技术 超声心动图描记技术 左心室 收缩功能 

分 类 号：R445.1[医药卫生—影像医学与核医学]