注射用灯盏花素与常用溶媒配伍稳定性考察  

Study on the Compatible Stability of Brevescapine Injection in Common Solvents

作　　者：王霞[1] 梅玲[1] 

机构地区：[1]成都市第五人民医院药剂科,成都611130

出　　处：《华西医学》2014年第2期293-296,共4页West China Medical Journal

摘　　要：目的考察注射用灯盏花素与临床常用溶媒的配伍稳定性。方法将注射用灯盏花素50 mg分别与100、250、500 mL三种规格的生理盐水、5%葡萄糖注射液、10%葡萄糖注射液配伍,放置0、1、2、4、6 h后观察配伍液的外观、测定溶液的pH值、采用高效液相色谱法测定配伍液中有效成分的含量变化。使用SPSS 15.0软件对采集的数据进行分析。结果供试品溶液在实验条件下外观无明显变化;pH值在标准范围内波动;与100 mL的生理盐水、100 mL的10%葡萄糖注射液配伍,及与以上三种规格的5%葡萄糖注射液配伍,主成分的含量变化均显著。结论注射用灯盏花素不宜与5%葡萄糖注射液配伍使用,最宜使用生理盐水250 mL或500 mL两种规格的溶媒进行配制,并在6 h内完成输注。Objective To study on the compatible stability of brevescapine injection in common solvents. Methods Brevescapine injection was added into 0.9% sodium chloride injection, 5% glucose injection, 10% glucose injection （100, 250, and 500 mL） respectively at room temperature. The pH value and visual appearance of the admixture were observed at immediate 0, 1, 2, 4, 6 hours after Brevescapine injection was added into the solvents. Scutellarin concentration was determined by the method of high performance liquid chromatography （HPLC）. Results No significant change was found in appearance and pH value of the admixture. And Scutellarin concentration changed obviously in the admixture of 100 mL 0.9% sodium chloride injection, 100 mL 10% glucose injection and the three types of 5% glucose injection. Conclusions Brevescapine injections have better compatibility with 250 mL and 500 mL 0.9% sodium chloride injection, and it is incompatible with 5% glucose injection. In addition, the admixture injection should be finished within six hours.

关 键 词：灯盏花素 野黄芩苷 配制 稳定性 

分 类 号：R969.3[医药卫生—药理学]