江苏无锡、新疆阿合奇地区健康人群血清胃蛋白酶原水平比较  

Comparison of serum pepsinogen level in healthy persons from Wuxi and Akqi

作　　者：范俊[1] 王涛 王亚鹏 任预应 陈万瑛 李向东 刘宗良[3] 张珏[1] 黄飚[1] 陈道桢[2,4] 

机构地区：[1]江苏省原子医学研究所,卫生部核医学重点实验室/江苏省分子核医学重点实验室,江苏无锡214063 [2]新疆阿合奇县人民医院 [3]无锡市第三人民医院 [4]南京医科大学附属无锡妇幼保健院

出　　处：《山东医药》2014年第7期20-22,共3页Shandong Medical Journal

基　　金：新疆维吾尔自治区科技支疆计划项目(2013911120);无锡市科技支撑计划项目(CSE01N1239)

摘　　要：目的 观察比较江苏无锡和新疆阿合奇地区健康人群血清中胃蛋白酶原（PG）含量的差异和分布情况.方法 选择江苏无锡居住健康体检正常者768例和新疆阿合奇县居住健康体检正常者792例,采用时间分辨荧光免疫法对两个地区健康人群血清中PG Ⅰ和PGⅡ进行测定,并计算PG Ⅰ/Ⅱ值.比较两地区不同性别、年龄（按≤20岁、21 ～30岁、31 ～40岁、41～50岁、51 ～60岁、＞60岁分组）、民族人群血清PG含量.结果 江苏无锡、新疆阿合奇地区血清中PG Ⅰ、PGⅡ和PG Ⅰ/Ⅱ值比较P均＜0.01.两地区健康人群PG Ⅰ和PG Ⅰ/Ⅱ与性别均有关（P＜0.05或＜0.01）,PGⅡ与性别均无关（P均＞0.05）；两地区男性血清中的PG Ⅰ、PGⅡ和PG Ⅰ/Ⅱ值比较P均＜0.01,女性血清中PGⅡ和PGⅠ/Ⅱ值比较P均＜0.01.无锡地区血清中PGⅠ、PGⅡ和PGⅠ/Ⅱ值均与年龄有关（P均＜0.01）,随年龄的增大呈上升趋势；阿合奇地区血清中各PG值与年龄均不相关.无锡、阿合奇地区21～30岁人群PGⅡ和PG Ⅰ/Ⅱ值比较P均＜0.01；31～40岁人群PG Ⅰ和PG Ⅰ/Ⅱ值比较P均＜0.01;41 ～50岁人群PGⅡ和PGⅠ/Ⅱ值比较P均＜0.01；＞60岁人群PG Ⅰ和PGⅠ/Ⅱ值比较P均＜0.01.阿合奇地区汉族、柯尔克孜族人群血清中的PGⅠ、PGⅡ和PGⅠ/Ⅱ值比较P均＞0.05,但阿合奇地区汉族和无锡地区汉族人群血清中PGⅡ和PGⅠ/Ⅱ值比较P均＜0.01.结论 江苏无锡、新疆阿合奇地区健康人群血清PG水平存在差异,且在性别分布上是一致的,在年龄分布上不一致.Objective To investigate and compare the difference of serum pepsinogen （PG） level in healthy persons between Wuxi and Xinjiang Akqi areas. Methods Totally 768 healthy persons from Wuxi and 792 healthy persons from Xinjiang Akqi area were selected. Serum PG level was detected by time-resolved fluorescence immunoassay （TRFIA）. The levels of serum PG I , PG Ⅱ and PG I /Ⅱ were detected. PG levels in different genders, ages （ ≤ 20, 21-30, 31-40, 41- 50, 51-60, 〉 60） and populations were compared between Wuxi and Xinjiang Akqi areas. Results The serum PG I , PG Ⅱ levels and PG I / Ⅱ ratio were significantly different between the two areas （ all P 〈 0. 01 ）. The serum PG I level and PG I / Ⅱ ratio were correlated with gender except PG Ⅱ in both the two areas. In the male serum, PG I , PG Ⅱ levels and PG I /Ⅱ ratio were significantly different between the two areas （ all P 〈 0.01 ） ; but in the female serum, PG N and PG I / Ⅱ ratio were significantly different between the two areas （ all P 〈 0. 01 ）. The serum PG levels were correlated with age in Wuxi area and increased with age but not in Xinjiang Akqi area （all P 〈0.01 ）. In Wuxi and Akql areas, PG Ⅱ and PG I /Ⅱ were significantly different in 21-30 and 41-45 healthy persons, as well as PG I and PG I/Ⅱ in 31-40 and 〉 60 healthy persons （ all P 〈 0. 01 ）. The serum PG levels had no significant difference between Han people and Kirgiz people in Akqi area. However, PG Ⅱ and PG I / Ⅱ were significantly different between Han people from Wuxi and Xinjiang Akqiarea （all P 〈 0. 01 ）. Conclusion Significant differences are found in the serum PG levels between Wuxi and Xinjiang Akqi area, and consistent in the sex distribution, inconsistent in the age distribution.

关 键 词：胃蛋白酶原 健康人群 地区比较 时间分辨荧光免疫分析法 

分 类 号：R446.11[医药卫生—诊断学]