静息状态下未服药首发重性抑郁症患者杏仁核功能连接的研究  

The Study on Functional Connectivity of Amygdala in First-episode Medication-naive Major Depressive Disorder During Resting-state

作　　者：张小崔[1] 雷辉[1] 朱雪玲[2] 朱熊兆[1] 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理学研究所,长沙410011 [2]国防科学技术大学人文与社会科学学院,长沙410074

出　　处：《中国临床心理学杂志》2014年第1期16-18,11,共4页Chinese Journal of Clinical Psychology

基　　金：湖南省研究生科研创新项目(CX2011B068);国家自然科学基金项目(81071104;30670709)

摘　　要：目的:采用静息态功能磁共振技术,探讨静息状态下未服药首发重性抑郁症患者杏仁核功能连接的异常改变。方法:对32例未服药首发重性抑郁症患者及35例健康对照者进行静息态功能磁共振成像扫描。以双侧杏儿核为感兴趣区,分别进行静息态脑功能连接分析。结果:与健康对照组相比,首发重性抑郁症患者左侧杏仁核与左侧眶额皮层的功能连接显著减弱。结论:情感网络中眶额皮层-杏仁核功能连接的异常可能是重性抑郁症的一个重要神经病理机制。Objective： Using resting-state functional magnetic resonance imaging technique, to study the functional con- nectivity of amygdale in first-episode, medication-naive patients with major depressive Disorder（MDD） during resting- state. Methords： Resting-state functional magnetic resonance imaging scans were performed in 32 first-episode, medica- tion-naive patients with MDD and 35 matched healthy controls（HC）. The resting-state functional connectivity was investi- gated using bilateral amygdala as seed regions. Results： Compared to HC, MDD patients showed reduced functional con- nectivity during resting-state between left amygdale and left orbitofrontal cortex（OFC）. Conclusion： In the affective net- work, abnormal functional connectivity between the amygdala and OFC may represent the important neuropathological mechanisms of MDD.

关 键 词：抑郁症 杏仁核 眶额皮层 磁共振成像 

分 类 号：R395.1[哲学宗教—心理学]