丙烯腈作业人群的脂质过氧化与抗氧化能力的观察  

Effects of Acrylonitrile Exposure on Lipid Peroxidation and Activities of Anti Oxidative Enzymes of Occupational Population

作　　者：唐钧[1] 范卫[2] 朱瑞娟[2] 应琪[2] 马来记[2] 陆荣柱[2] 

机构地区：[1]复旦大学医学院金山医院检验科,上海200540 [2]复旦大学医学院金山医院职业病防治所,上海200540

出　　处：《工业卫生与职业病》2001年第1期11-13,共3页Industrial Health and Occupational Diseases

摘　　要：选取 78名接触丙烯腈 (ACN)的作业人员为接触组 ,并以 73名不接触任何毒物的健康人作为对照 ,测定血清中丙二醛 (MDA)、超氧化物歧化酶 (SOD)和谷胱甘肽过氧化物酶 (GSH -Px)。结果提示 ,接触组的SOD和GSH -Px的活性明显下降 ,而MDA未见升高。经对吸烟、性别进行分层分析 ,也未发现差别有显著性 ,因而本次研究表明ACN能降低机体的抗氧化能力 。In order to explore the effects of acrylonitrile exposure on lipid peroxidation and activities of anti oxidative enzymes of occupational population,78 workers occupationally exposed to acrylonitrile were selected as the exposure group,and 73 workers without any exposure to chemical toxicants and other hazards served as the control group.Two groups were statistically similar about sex,age and smoking habit.MDA,and activities of SOD and GSH Px in serum were determined in two groups.The results showed that the activities of SOD and GSH Px of the exposure group were significantly lower than those of the control group,but the level of MDA of the exposure group was higher than that of the control group without statistical significance.In addition,when stratified by sex,smoking habit and duration of exposure,no statistical difference could be found.The results suggest that acrylonitrile exposure can decrease the ability to delete the reactive oxygen species,it is needed to further and comprehensively evaluate the oxidative and anti oxidative status of workers.

关 键 词：丙烯腈 脂质过氧化 生物监测 

分 类 号：R114[医药卫生—卫生毒理学] R735.1[医药卫生—公共卫生与预防医学]