3-羟基-4-吡啶酮衍生物的合成及与Fe^(3+)螯合性能  

Synthesis of 3-Hydroxy-4-pyridinone Derivative and its Chelating Property with Iron(Ⅲ) Ion

作　　者：马越[1] 彭汝芳[1] 金波[1] 陈晓娟[1] 郑荣宗[1] 楚士晋[1] 

机构地区：[1]西南科技大学四川省非金属复合与功能材料重点实验室-省部共建国家重点实验室培育基地,四川绵阳621010

出　　处：《精细化工》2014年第3期294-298,共5页Fine Chemicals

基　　金：国家自然科学基金(21301142);碳纳米材料四川省青年科技创新研究团队(2011JTD0017);四川省教育厅重点项目(13ZA0172)~~

摘　　要：以甲基麦芽酚、对苯二胺、丙二酰氯为主要原料,微波辅助合成得到N,N'-二[对-(2-甲基-3-羟基-4-吡啶酮)苯基]丙二酰胺。采用IR、1HNMR、UV-vis、MS对产物结构进行了确证。采用分光光度法测定了该化合物对Fe3+的螯合性能,结果表明,在pH=7.40的Tris-水-乙醇缓冲溶液中,配体与Fe3+的配位比为1∶1,配合物表观稳定常数为lgK=7.76,证实该化合物对Fe3+具有潜在的螯合能力。N, N＇-bis-[ 4-（ 2-methyl-3-hydroxy-4-pyridinone ） -phenyl ]-malonamide was prepared by microwave-assisted synthesis with methyl maltol,p-phenylenediamine, malonyl dichloride as the main raw materials. The structure of the target product was characterized by means of IR, 1HNMR, UV-vis and MS. And its chelating property with iron （III ） ion has been measured by spectrophotometric determination. The results show that, at pH = 7.40, the ligand coordination with Fe3 is 1 ： 1 under the Tris-water-ethanol buffer solution, and that the apparent stability constant of the complex is lgK = 7.76, which confirms that the novel compound has potential chelating potency for iron（ III ） ion.

关 键 词：3-羟基4-吡啶酮 Fe(111)配合物 功能材料 

分 类 号：R973.3[医药卫生—药品] TQ314.269[医药卫生—药学]