A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum  

作　　者：LIU Dan QU Wei ZHAO Ling GUAN Fu-Qin LIANG Jing-Yu 

机构地区：[1]Department of Natural Medicinal Chemistry, China Pharmaceutical University [2]College of Biotechnology and Pharmaceutical Engineering, Wuhan Polytechnic University [3]Institute of Botany,Jiangsu Province and Chinese Academy of Science

出　　处：《Chinese Journal of Natural Medicines》2014年第2期139-141,共3页中国天然药物（英文版）

基　　金：supported by the Fundamental Research Funds for the Central Universities,China(No.JKY2011015)

摘　　要：AIM: To study the chemical constituents of the rhizomes of Alpinia officinarum Hance. METHOD: Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay. RESULTS: A dimeric diarylheptanoid, named alpinin B(1), along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B(1), 1, 7-diphenyl-3,5-heptanedione(2),(4E)-1, 7-diphenylhept-4-en-3-one(3) and(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(4). CONCLUSION: Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol L 1.AIM： To study the chemical constituents of the rhizomes ofAlpinia officinarum Hance. METHOD： Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B 16F10 cell lines by the MTT assay. RESULTS： A dimeric diarylheptanoid, named alpinin B （1）, along with three known diarylheptanoids were obtained, and their structures were identified as alpinin B （1）, 1, 7-diphenyl-3,5-heptanedione （2）, （4E）-1, 7-diphenylhept-4-en-3-one （3） and （4E）-7- （4-hydroxyphenyl）- 1-phenylhept-4-en-3-one （4）. CONCLUSION： Compound 1 is a new dimeric diarylheptanoid. The biosynthetic pathway of 1 was speculated to originate from a Michael reaction between compounds 2 and 3. Compound 3 showed cytotoxicity against the human glioblastoma T98G cell line with IC50 of 27 μmol·L-1.

关 键 词：Alpinia officinarum Hance DIARYLHEPTANOID alpinin B 1 7-diphenyl-3 5-heptanedione （4E）-l 7-diphenylhept-4-en -3-one 

分 类 号：R284.1[医药卫生—中药学]