Two new steroidal saponins from the rhizomes of Dioscorea zingiberensis  

作　　者：ZHENG Lu ZHOU Yuan ZHANG Jia-Yu SONG Min YUAN Ye XIAO Yan-Jiao XIANG Ting 

机构地区：[1]Research Institute of Traditional Chinese Medicine,Yangtze River Pharmaceutical Group Co., Ltd. [2]School of Chinese Pharmacy, Beijing University of Chinese Medicine

出　　处：《Chinese Journal of Natural Medicines》2014年第2期142-147,共6页中国天然药物（英文版）

基　　金：supported by the Science and Technology Achievement Transformation Project of Jiangsu Province(No.BA2010144);the scientific and technological major special project for "Significant Creation of New Drugs"(No.2012ZX09101231)

摘　　要：AIM: To investigate the chemical constituents of Dioscorea zingiberensis C. H. Wright. METHODS: The compounds were isolated by various chromatographic techniques, and the structures of the new steroidal saponins were elucidated by extensive 1D- and 2D-NMR, MS, and IR spectral analysis. RESULTS: The 70% EtOH extract of the rhizomes of Dioscorea zingiberensis afforded two new steroidal saponins, zingiberenosides A(1) and B(2), along with eight known analogues, 3β, 26-dihydroxy-25(R)-furosta-△5, 20(22)-diene-3-O-α-Lrhamnopyranosyl-(1→2)-O-β-D-glucopyranoside(3), methyl parvifloside(4), deltoside(5), methyl deltoside(6), zingiberensis new saponin(7), deltonin(8), progenin III(9) and diosgenin-diglucoside(10). CONCLUSION: Two new steroidal saponins were isolated from Dioscorea zingiberensis and their structures determined.AIM： To investigate the chemical constituents of Dioscorea zingiberensis C. H. Wright. METHODS： The compounds were isolated by various chromatographic techniques, and the structures of the new steroidal sapon- ins were elucidated by extensive 1D- and 2D-NMR, MS, and IR spectral analysis. RESULTS： The 70% EtOH extract of the rhizomes of Dioscorea zingiberensis afforded two new steroidal saponins, zingiberenosides A （1） and B （2）, along with eight known analogues, 3fl, 26-dihydroxy-25（R）-furosta-As＇ 20（22）-diene-3-O-a-L- rhamnopyranosyl-（1→2）-O-β-D-glucopyranoside （3）, methyl parvifloside （4）, deltoside （5）, methyl deltoside （6）, zingiberensis new saponin （7）, deltonin （8）, progenin III （9） and diosgenin-diglucoside （10）. CONCLUSION： Two new steroidal saponins were isolated from Dioscorea zingiberensis and their structures determined.

关 键 词：Dioscorea zingiberensis DIOSCOREACEAE Steroidal saponins Zingiberenoside 

分 类 号：R284.1[医药卫生—中药学]