颈动脉粥样硬化患者外周血Th17水平研究  

Analysis of Th17 cells in peripheral blood in patients with carotid atherosclerosis

作　　者：朱太卿[1] 张莉峰 袁学谦[1] 肖悠美[1] 张存玲[1] 王慧贞[1] 王焕荣[1] 王爱丽[1] 

机构地区：[1]郑州人民医院神经内科,郑州450003

出　　处：《中国实用神经疾病杂志》2014年第3期50-51,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的本研究通过检测颈动脉粥样硬化患者外周血Th17的水平,探讨Th17细胞在颈动脉粥样硬化发病中的作用。方法利用流式细胞术检测颈动脉粥样硬化患者组(36例)和正常对照组(36例)外周血Th17细胞水平,利用ELISA法检测患者组和对照组外周血浆IL-17的水平。结果与正常对照组(0.74±0.25)比较,颈动脉粥样硬化患者组(1.78±0.39)Th17细胞水平显著升高,差异有统计学意义(P<0.01)。与正常对照组[(12.32±1.54)pg/mL]比较,颈动脉粥样硬化患者组[(18.57±1.91)pg/mL]IL-17水平显著升高,差异有统计学意义(P<0.05)。结论外周血Th17的升高可能参与了颈动脉粥样硬化患者病程的发生和进展。Objective To explore the role of Th17 cell in the progress of carotid atherosclerosis by detecting the level of Th17 cells in peripheral blood mononuclear cells（PBMNCs） of the disease. Methods Carotid atherosclerosis group （36 cases） and healthy controls （HC） group （36 cases） were investigated. The level of Th17 cell and IL-17 were respectively detected by Flowcytometry and ELISA. Results Compared with HC group, the level of Th17 cells increased significantly （P〈0.01） in carotid atherosclerosis group （（0.74±0.25）% vs. （1.78±0.39）%）. Compared with HC group, the level of IL-17 increased significantly （P〈0.05） in carotid atherosclerosis group（（12. 32±1.54）pg/mL vs. （18. 57±1.91）pg/mL）. Conclusion Th17 cell may play an important role in the progress of carotid atherosclerosis.

关 键 词：TH17 细胞 白介素17 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]