托特罗定与胫神经电刺激治疗膀胱过度活动症的随机单盲对照试验研究  

The single-blind randomized controlled study of Tolterodine and tibial nerve stimulation for the treatment of overactive bladder

作　　者：李富林[1] 黄栋强[1] 黄锐[1] 

机构地区：[1]广东惠州市第一人民医院泌尿外科,惠州516000

出　　处：《中国实用神经疾病杂志》2014年第4期34-36,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析托特罗定与胫神经电刺激治疗膀胱过度活动症的临床治疗效果。方法随机选取我院近一年来收治的膀胱过度活动症患者48例,随机分为试验组与对照组,每组各24例,其中试验组采用口服托特罗定联合胫神经电刺激治疗,对照组单纯口服托特罗定治疗,对比2组治疗情况及日排尿次数。结果试验组治疗总有效率(83.33%)明显高于对照组(37.50%),试验组治疗后日均排尿次数[(7.2±2.8)次]明显低于治疗前[(12.4±3.6)次]及对照组[(9.8±3.2)次],差异有统计学意义(P<0.05)。结论托特罗定单独治疗膀胱过度活动症的治疗效果并不理想,但该药联合胫神经电刺激治疗疗效显著,且无不良反应,安全性较高,值得在临床推广。Objective To investigate and analyze of clinical efficacy of Toherodine and tibial nerve stimulation on overac- tive bladder. Methods 48 cases with overactive bladder in the past one year from our hospital were randomly selected and were randomly divided into the experimental group and the control group, each group with 24 cases, of which the experimental group were treated with oral tolterodine and tibial nerve stimulation for the treatment, the control group were treated purely oral toherodine. The treatment and day frequency of urination of two groups were compared. Results The total effective rate of the experimental group （83.33 %） was significantly higher than that of the control group （37.50%）. After treatment, daily mictu- rition frequency of the experimental group （7.2 ± 2.8）times was significantly lower than that before treatment （12.4 ± 3.6） times as well as that of the control group before and after treatment E（12.6 ± 3.8） times, （9.8±± 3.2] times] （P〈0.05）. Conclusion Toherodine monotherapy has no ideal efficacy on overactive bladder, but it combined with tibia[ nerve stimulation has a significant efficacy on this disease, and has no adverse reactions with high security, so it is worthy of promotion.

关 键 词：膀胱过度活动症 托特罗定 胫神经电刺激治疗 

分 类 号：R694.5[医药卫生—泌尿科学]