高血压患者血清瘦素水平与有创动脉血压的关系  

Relationship between serum level of leptin and the Innasive blood pressures in Hypertension patients.

作　　者：孙利强[1] 李晶[2] 李恩[1] 简立国[1] 

机构地区：[1]郑州大学第二附属医院心血管内科,郑州450014 [2]郑州大学第二附属医院核医学科,郑州450014

出　　处：《中国实用神经疾病杂志》2014年第4期46-47,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨高血压患者血清瘦素(LEP)水平与中心动脉压及外周桡动脉压的关系。方法收集我院2012-3-12,231例高血压合并冠心病进行冠状动脉造影的患者,冠状动脉造影结束后,采用造影导管测量升主动脉根部及外周桡动脉内血压。冠状动脉造影前采集外周静脉血用酶联免疫吸附法(ELISA)检测血清LEP水平。采用Spearman相关性分析研究血清瘦素(LEP)水平与中心动脉压及外周桡动脉压的关系。结果血清LEP水平与中心动脉及外周桡动脉收缩压、平均动脉压和脉压均呈正相关;而与中心动脉及外周桡动脉舒张压无相关性。结论血清LEP水平随中心动脉及外周桡动脉内收缩压、平均动脉压和脉压升高而升高,与中心动脉及外周桡动脉内舒张压无关。Objective To analyze the relationship between serum level of leptin and the peripheral arterial and the central arterial blood pressures. Methods 231 cases who underwent the coronary angiography were collected. The simultaneous the systolic blood pressure （SBP） and diastolic blood pressure（DBP） of the ascending aorta and radial artery were recorded postop- eratively, and mean artery pressure（MAP） and pulse pressure（PP） were calculated. The serum level of leptin were measured by Enzyme-Linked Immunosorbnent Assay（ELISA）. Results The serum level of leptin were all correlaled positively with SBP, MAP and PP of the peripheral and aortic pressures, but there was no correlation between the serum level of leptin and DBP of the peripheral and aortic pressures. Conclusion The serum level of leptin may be correlaled with SBP, MAP and PP of the pe- rioheral and aortic pressures.

关 键 词：瘦素 中心动脉压 外周桡动脉压 

分 类 号：R544.1[医药卫生—心血管疾病]