乙肝病毒抗原抗体与HBV-DNA的临床研究  

The clinical study on antigen/antibody and DNA of HBV

作　　者：张业霞[1] 金玉怀[2] 

机构地区：[1]菏泽医学专科学校病原教研室,山东菏泽274000 [2]河北医科大学,河北石家庄050017

出　　处：《中国现代医生》2014年第6期48-50,53,共4页China Modern Doctor

摘　　要：目的探讨前S1抗原、前S1抗体、前S2抗原、前S2抗体、HBV五项指标和DNA及肝功之间的相互关系及意义。方法对急性和慢性乙肝患者各30例的初诊及3个月、6个月血清中的HBV上述指标联合检测。结果在急性乙肝早期,前S1抗原、前S2抗原、HBsAg、HBeAg的检测与DNA检测高度一致,但在晚期DNA仍是最佳检测手段,其他单一指标的阳性率均低于DNA检测。在慢性乙肝的不同时期,前S1抗原与DNA检测高度一致,其余各项检测方法均未达到理想的效果。结论在急性乙肝早期,前S1抗原、前S2抗原、HBsAg、HBeAg的检测可作为DNA检测的替代方法,但在晚期仍要依靠DNA的检测,在慢性乙肝的不同时期,前S1抗原与DNA检测高度一致,在一定程度上可替代DNA,但为避免漏诊,需综合考虑多项指标。Objective To study the significance and relationship among preS1, anti-preS1, preS2, anti-preS2, five indicators and DNA about HBV and liver function. Methods Collected 30 cases with acute hepatitis B and 30 with chronic hepatitis B. The joint detection was observed in the first visit, 3 months and 6 months later. Results In the test results of Acute hepatitis B group, the figures about the detection of preS1, preS2, HBsAg, HBeAg were coincide with the detection of DNA, but in the late, DNA was still the best means of detection, the positive rate of other single index were lower than that of DNA detection. In different stages of chronic hepatitis B, the detection of preS1 and DNA were highly consistent, the other detection methods had not achieved the ideal effects. Conclusion The detection of acute hepatitis B in the early, the preS1, preS2, HBsAg and HBeAg may be used as an alternative method for DNA detection, but we still rely on the detection of DNA in the late, at different stages of chronic hepatitis B, the detection of PreS1 antigen is highly consistent with DNA, which can replace the detection of DNA in some extent,but we should think many indexs in order to avoid missed diagnosis.

关 键 词：HBV-DNA 前S1抗原与抗体 前S2抗原与抗体 

分 类 号：R512.62[医药卫生—内科学]