乙型肝炎病毒宫内传播的危险因素  

Risk Factors of HBV Intrauterine Transmission

作　　者：詹前胜[1] 谭丽君[1] 

机构地区：[1]中山医科大学附属第一医院妇产科,广东广州510080

出　　处：《中山医科大学学报》2001年第1期61-63,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：【目的】研究乙型肝炎病毒宫内传播的危险因素。【方法】对 87例乙肝表面抗原阳性孕妇采集脐血行乙肝标志物、PCR HBV DNA检测 ,孕妇产后 1～ 4d内取静脉血进行乙肝标记物检测。【结果】脐血PCR HBV DNA阳性 1例占 1 2 %(1/ 86 )。母血HBsAb、HBeAg、HBeAb、HBcAb的宫内感染的危险度 (OR)分别为 0 6 97(0 5 86～ 0 786 )、5 0 792 (13 0 82～197 2 0 4)、0 10 3(0 0 32～ 0 338)、2 2 6 1(0 5 87～ 8 712 )。母血HBeAg阳性 (含HBcAb阳性 )组的脐血HBsAg阳性百分数(31 0 % )、HBeAg阳性百分数 (72 4% )显著高于HBsAg阳性组 (分别为 3 92 % ,3 92 % )。性别与是否宫内感染无显著相关 ,母血HBeAg与脐血HBsAg特别是HBeAg显著相关。【结论】孕妇血中HBeAg阳性是胎儿宫内感染的危险因素 ;新生儿性别与宫内感染无关。Objective To study the risk factors of Hepatitis B Virus intrauterine transmission. Method Cordal blood from 87 HBV carrier's newborns was tested for HBV markers and PCR-HBV-DNA. Maternal venous blood postpartum was tested for HBV markers. Results HBV-DNA positive rate of cordal blood is 1.2%(1/86). Odds Ratio(OR) of positive maternal HBsAb, HBeAg, HBeAb and HBcAb for intrauterine infection are 0.697(0.586～0.786), 50.792(13.082～197.204), 0.103(0.032～0.338) and 2.261(0.587～8.712), respectively. Cordal HBsAg positive rate of maternal HBeAg positive group was significantly higher than that of only HBsAg positive group (31.0% vs 3.92%), so was cordal HBeAg positive rate (72.4% vs 3.92%). Maternal HBeAg was significantly correlated with cordal HBsAg, especially HBeAg. Newborn sex wasn′t correlated with intrauterine infection. Conclusion Positive maternal HBeAg was one risk factor of intrauterine HBV infection. Newborn sex wasn′t correlated with intrauterine infection.

关 键 词：乙型肝炎 宫内传播 垂直传播 危险因素 胎血 

分 类 号：R512.62[医药卫生—内科学]