大鼠体质量对1型糖尿病造模成功率的影响  

Influence of body mass on the success rate of modeling in type 1 diabetes

作　　者：陈静[1] 冯波[1] 王成 林菁艳[2] 

机构地区：[1]川北医学院,四川南充629213 [2]川北医学院附属医院麻醉学系,四川南充629213

出　　处：《现代医药卫生》2014年第5期670-671,共2页Journal of Modern Medicine & Health

基　　金：四川省教育厅科研基金资助项目(11ZA192)

摘　　要：目的探讨大鼠体质量对1型糖尿病造模成功率的影响。方法选取7-9周龄SD大鼠35只，体质量180～270g，根据体质量分为三组：A组（n=11）180-210g，B组（n=12）〉210-240g，C组（n=12）〉240-270g。适应性喂养1周后，所有大鼠均腹腔注射6％链脲佐菌素60mg／kg，72h后测定空腹血糖并观察大鼠存活情况。结果A组和B组大鼠造模成功率明显高于C组，差异有统计学意义（P〈0．05）。结论体质量180-240g大鼠1型糖尿病成模率较高。随着体质量的增加。成模率会降低，死亡率增大。Objective To explore the influence of rat body mass on the success rate of modeling in type 1 diabetes. Methods Totally 35 SD rats with only 7-9 weeks were divided into three groups according to the body mass ： group A （n= 11 ） with 180-210g, group B （n= 12） with 〉210-240 g and group C （n= 12） with 〉240-270 g. Fed adaptively for 1 week, all the rats were with intraperitoneal injection with 6% streptozotocin （STZ） 60mg/kg.The fasting blood glucose （FBG） was determined after 72 h and their survival situation was observed. Results The success rate of modeling in group A and group B was obviously higher than that in group C （P〈0.05）. Conclusion The rats with type 1 diabetes from 180 g to 240 g have higher success rate of modeling. With increase of body mass, the success rate of modeling reduces, while the fatality rate increases.

关 键 词：大鼠 Sprague—Dawley 疾病模型 动物 糖尿病 1型 体重 成模率 

分 类 号：R587.1[医药卫生—内分泌]