通腑泻肺方治疗AECOPD痰热壅肺证临床研究  

The Effect of Purgating fu-Organs to Eliminate Lung Prescription on AECOPD Patients and on AQP5

作　　者：李淑芳[1] 熊旭东[1] 施荣[1] 庞辉群[1] 

机构地区：[1]上海中医药大学附属曙光医院,上海200021

出　　处：《中国中医急症》2014年第2期223-226,共4页Journal of Emergency in Traditional Chinese Medicine

基　　金：上海市科委中药现代化专题项目(10dz1973100)

摘　　要：目的观察通腑泻肺方对慢性阻塞性肺疾病急性加重(AECOPD)的疗效,探讨其对C反应蛋白(CRP)、水通道蛋白5(AQP5)的影响。方法将AECOPD患者随机分为治疗组和对照组,两组均以西医常规方法为基础治疗,治疗组加用通腑泻肺方,对照组加用安慰剂。观察两组治疗前后证候情况,检测两组治疗前后血气分析、CRP、AQP5结果。结果 (1)治疗组的总有效率高于对照组,但差异无统计学意义(P>0.05)。(2)与治疗前比较,两组在治疗后第5、10日咳嗽、痰量、气喘积分较前降低(P<0.05或P<0.01);两组治疗后同期比较,治疗组在第5日、10日痰量、气喘积分均较对照组降低(P<0.05)。(3)与治疗前比较,治疗组在治疗后第10日PaO2及SaO2较前明显增加,PaCO2明显下降(P<0.05);对照组治疗后第10日PaO2及SaO2较前明显增加(P<0.05)。两组治疗后比较,治疗组治疗第10日后PaCO2下降较对照组明显(P<0.05)。(4)与治疗前比较,治疗组治疗后CRP明显下降,AQP5升高明显(P<0.05)。两组治疗后比较,CRP、AQP5水平差异均无统计学意义(P>0.05)。结论通腑泻肺方的干预治疗明显提高AECOPD疗效,改善AECOPD患者咯痰、气喘症状降低PaCO2,干预机制可能与降低CRP、提高AQP5水平有关。Objective： To observe the effect of Purgating fu-Organs to Eliminate Lung Prescription on AECOPD patient and to study its effect on AQP5. Methods： Adopt randomized paeebo-eontrolled double-blind clinical tri- al method. AECOPD patients were randomly divided into two groups,i.e, treatment group and placebo group. The two groups were treated with basic treatment （conventional therapy of Western medicine）. The treatment group added Purgating fu-Organs to Eliminate Lung Prescription on the basis while the placebo group added placebo. Before and after treatment the symptoms were observed. Blood-air analysis and the level of CRP,AQP5 were de- tected in the two groups. Results： 1.Of the Per-Protocol Population AECOPD patients,the effective rate of treat- ment group was higher than that of placebo group ,but the difference had no statistical significance （P〉 0.05 ）. 2. Compared with before ,the score value of Cough, Phlegm,and Asthma significantly reduced in the two groups after the fifth and tenth days （P〈 0.05 or P〈 0.01 ）. The two groups compared after treatment at the same time. The score value of Phlegm, Asthma significantly reduced in treatment group after the fifth and tenth days （P〈 0.05）. 3. Compared with before,the level of PaO2 and SaO2 increased significantly and the level of PaCO2 reduced signifi- cantly in treatment group after the tenth day （P〈 0.05）. The level of PaO2 and SaO2 increased significantly after the tenth day （P 〈 0.05） in control group. The two groups compared after treatment. The level of PaCO2 reduced significantly in treatment groups after the tenth day （P〈 0.05）. 4. Compared with before, the level of CRP reduced significantly while the level of AQP5 increased significantly in treatment group after treatment （P〈0.05） ,the two groups compared after treatment. The level of CRP ,AQP5 had no statistical difference （P〉 0.05）. Conclusions： Purgating fu- Organs to Eliminate Lung Prescription can improve the symptoms such as Phlegm,Asthm

关 键 词：慢性阻塞性肺疾病急性发作 通腑泻肺方 安慰剂对照 水通道蛋白5 痰热壅肺 

分 类 号：R563.9[医药卫生—呼吸系统]