炙甘草汤主要有效成分对心肌生理特性的影响  

Studies on effect of main active principles in ZHIGANCAO DECOCTION on myocardial electrophysiology

作　　者：陈兰英[1] 陈奇[1] 刘荣华[1] 毕明[1] 周丽娟[1] 李文宏[1] 

机构地区：[1]江西中医学院,江西南昌330006

出　　处：《中草药》2001年第2期134-136,共3页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目!(3986 0 0 84);江西省自然科学基金资助项目!(945 35 )

摘　　要：目的　观察炙甘草汤主要有效成分及部位对大鼠离体心肌生理特性的影响。方法　采用大鼠离体心房肌和心乳头肌 ,研究药物对心肌自律性、心奋性和功能不应期的作用。结果　甘草酸、人参总皂苷和麦冬总皂苷合用能明显降低大鼠离体右心房肌自律性和左心房肌心奋性 ,明显延长大鼠离体左心房肌功能不应期 ,明显抑制肾上腺素诱发大鼠离体乳头状肌自律性和心律失常 ,而缺少这 3种成分的炙甘草汤作用明显低于炙甘草汤全方。结论甘草酸。Object To study the influence of main active principles of ZHIGANCAO DECOCTIDN (ZD), glycyrrhizic acid (GA), ginseng total saponin (GTS) and Ophiopogon total saponin (OTS) on electrophysiology of isolated rat myocardium Methods The influence of GA, GTS and OTS on the automaticity, excitability and functional refractory period of isolated rat atrium and papillary muscle were studied in comparison with ZD made free of the above said active ingredients Results The combine use of GA, GTS and OTS significantly decreased the automaticity, inhibited excitaibility and prolonged the functional refractory period of isolated rat atrium; decreased the automaticity and arrhythmia of papillary muscle induced by epinephrine, while ZD made free of GS, GTS and OTS showed much less effect than the intact decoction Conclusion GA, GTS and OTS proved to be the main effective ingredients responsible for the antiarrhythmic activity of ZD

关 键 词：炙甘草汤 甘草酸 人参总皂苷 麦冬总皂苷 心肌生理特性 中药 心肌疾病 有效成分 

分 类 号：R259.422[医药卫生—中西医结合] R285[医药卫生—中医内科学]