心泰平抗实验性心律失常作用的研究  

Experimental studies on the antiarrhythmic effect of Xintaiping

作　　者：陈庆文[1] 孙建平[1] 张永春[1] 罗大力[1] 何树庄[1] 杨宝峰[1] 

机构地区：[1]哈尔滨医科大学药理学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2001年第1期1-3,共3页Journal of Harbin Medical University

基　　金：国家自然科学基金资助项目!( 3 9870 92 2 )

摘　　要：目的　观察心泰平对多种实验性心律失常的拮抗作用以及对大鼠血流动力学和心电图 (ECG)的影响。方法　采用乌头碱、BaCl2 、电刺激和冠脉结扎诱发大鼠及家兔心律失常的 4种实验动物模型 ,观察心泰平口服给药对心律失常的防治作用 ;大鼠左心室内插管 ,多道生理记录仪检测血流动力学指标和ECG。结果　心泰平生药 4g/kg与 8g/kg明显延迟大鼠乌头碱性心律失常的出现时间 (P <0 .0 1) ,降低室颤发生率 ,提高窦性节律恢复率 ,并显著提高家兔电刺激的室颤阈 (P <0 .0 1) ,对大鼠BaCl2 和冠脉结扎性心律失常也有一定的对抗作用 ;生药 8g/kg可降低大鼠左室收缩压 (LVSP)和 -dp/dtmax(P <0 .0 5 ) ,延长Q T间期 (P <0 .0 5 ) ,无负性频率和传导作用。结论　心泰平可防治多种心律失常 ,尤以功能性为佳 ,且对心脏抑制作用小。Objective To study the effects of Xintaiping(XTP) on experimental arrhythmias,hemodynamics and ECG.Methods Using the animal arrhythmic models induced by aconitine,BaCl 2,electric stimulation and coronary artery ligation,hemodynamics and ECG were assessed by means of left ventricular catheterization using a polygraph system in rats.Results XTP 4g/kg and 8g/kg prolonged significantly the onset time of aconitineinduced arrhythmias in rats( P <0.01),decreased the incidence of VF,and increased the threshold of electric stimulation induced VF in rabbits ( P <0.01).XTP could also counteract arrhythmias induced by BaCl 2 and coronary occlusion in rats.XTP 8g/kg decreased LVSP and -dp/dt max in rats( P <0.05),prolonged Q T interval( P <0.05),but didn't affect dp/dt max ,SAP,heart beat and A V.Conclusion XTP is a traditional Chinese herb with little heart inhibition,protectes the animals well from experimental arrhythmias,especially induced by aconitine and electric stimulation.

关 键 词：心泰平 心律失常 血流动力学 心电图 中医药治疗 大鼠 

分 类 号：R259.417[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]