曲美他嗪治疗冠心病伴糖尿病的疗效观察  

Efficacy of trimetazidine in coronary diabetic patients with stable effort angina

作　　者：林钟文[1] 吴盛标[1] 吴胜楠[1] 陈科奇[1] 陈永久[1] 

机构地区：[1]暨南大学医学院附属深圳市人民医院心内科,深圳518020

出　　处：《临床心血管病杂志》2001年第2期66-67,共2页Journal of Clinical Cardiology

摘　　要：目的 :观察曲美他嗪治疗伴有糖尿病的冠心病 (CHD)治疗效果。方法 :用曲美他嗪治疗 CHD伴有糖尿病 (A组 )与不伴有糖尿病 (B组 )两组各 4周 ,对两组治疗前后平板运动耐量指标变化进行对照。结果 :两组在治疗后的运动总步行时间、运动至心绞痛出现时间和运动到 ST段压低达到 0 .1m V所需时间均较治疗前有明显延长 (P <0 .0 5 ) ,但 A组的效果比 B组更显著 (P <0 .0 5 )。结论 :曲美他嗪治疗伴有糖尿病的 CHD效果比不伴有糖尿病的 CHD更显著。Objective:To evaluate whether trimetazidine is more beneficial in coronary diabetic patients with stable effort angina than in coronary artery disease patients without diabetes.Method:Coronary artery disease patients with diabetes (group A) and without diabetes (group B) received trimetazidine for 4 weeks.The tolerance of exercise stress tests was compared between these two group befroe and after the trial.Result:All cases showed a significant improvement in total exercise walking time,time to onset of anginal pain and time to 0.1 mV ST segment depression (P< 0.05 ) after the combination therapy with trimeatzidine,which was more significant in coronary diabetic patients than in coronary artery disease patients without diabetes (P< 0.05 ).Conclusion:In coronary artery disease patients with diabetes,combination therapy with trimetazidine has more significant effect than in those without diabetes.

关 键 词：糖尿病 曲美他嗪 冠心病 并发症 药物治疗 

分 类 号：R541.406[医药卫生—心血管疾病] R587.205[医药卫生—内科学]