曲美他嗪对稳定型劳力性心绞痛患者心肌缺血的影响  

Effect of trimetazidine on myocardial ischemia in patients with stable angina pectoris

作　　者：庞红[1] 林华[1] 张金枝[1] 黄佩霞[1] 

机构地区：[1]华中科技大学同济医学院心血管病研究所

出　　处：《临床心血管病杂志》2001年第2期68-69,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨曲美他嗪对冠心病 (CHD)稳定型劳力性心绞痛患者心肌缺血的影响。方法 :选择经冠状动脉造影确诊的 CHD稳定型劳力性心绞痛患者 14例 ,在原有治疗不变的情况下 ,加用曲美他嗪治疗 12周 ,治疗前后均行平板运动试验 ,观察用药前后下述指标的变化 :1用药前后每周心绞痛发作的次数 ;2每周硝酸甘油片的用量 ;3心率及心率和收缩压的乘积 ;4运动诱发心绞痛发作所需的时间 ;5运动后 ST段下降 0 .1m V所需的时间 ;6运动持续时间。结果 :患者每周心绞痛发作的次数及硝酸甘油片的用量均明显下降 (P <0 .0 5 ) ;心率及心率和收缩压乘积轻度变化 (P>0 .0 5 ) ;明显延长运动诱发心绞痛所需的时间及运动后 ST段下降≥ 0 .1m V所需的时间 (P <0 .0 5 )。结论 :曲美他嗪能改善运动诱发的心肌缺血 ,对 CHD劳力性心绞痛患者有一定的疗效。Objective: To evaluate the efficacy of trimetazidine on myocardial ischemia in patients with stable angina pectoris.Method:Fourteen angiographically proven coronary artery disease patients with routine treatment were given trimetazidine for 12 weeks.Treadmill exercise testing was adopted and the following indexes were invesgated before and after therapy:① times of angina petoris attack everyweek;②consumption of nitroglycerin every week;③heart rate,systolic pressure and their product;④time for inducing angina by exercise;⑤time for inducing 0.1 mV ST segment depression by exercise;⑥the total exercise time.Result:After therapy of trimetazidine,angina petoris attack and consumption of nitroglycerin every week were decreased obviously(P< 0.05 ).Heart rate,systolic pressure and their product changed slightly(P> 0.05 ).The total exercise time was prolonged with no significant difference,but the time for inducing angina and 0.1 mV ST segment depression by exercise were prolonged obviously(P< 0.05 ).Conclusion:Trimetazidine can improves myocardial ischemia induced by exercise and has obvious efficacy on patients with stable angina pectoris.

关 键 词：稳定型劳力性心绞痛 曲美他嗪 心肌缺血 影响 

分 类 号：R541.406[医药卫生—心血管疾病] R542.205[医药卫生—内科学]