米非司酮配伍米索前列醇终止早孕3种给药间隔比较  

Comparison of 3 intervals between mifepristone and misoprostol administration for the termination of early pregnancy

作　　者：张岚蓉[1] 张爱[1] 陆志洁[1] 杨宾烈[1] 茅晓燕[1] 

机构地区：[1]上海市浦东新区人民医院妇产科,上海201200

出　　处：《世界临床药物》2014年第2期92-95,共4页World Clinical Drug

基　　金：上海市浦东新区卫生系统优秀青年医学人才培养计划(No.PWRq2011-23)

摘　　要：目的比较米非司酮配伍米索前列醇3种给药间隔对早孕药物流产效果的影响。方法 450例早孕要求行药物流产的健康孕妇随机分为组1、组2和组3(n=150)。3组孕妇顿服米非司酮200 mg后分别于12、24和48 h口服米索前列醇0.6 mg,观察并随访3组流产效果及药物不良反应。结果组2和组3的完全流产率分别为91.33%和92.00%,组间差异无统计学意义,组1完全流产率为82.00%,低于组2或3,组间差异显著(P<0.01)。各组病例均未发生严重不良反应。结论药物终止早孕的用药方案中,顿服米非司酮200 mg后,口服米索前列醇0.6 mg的给药间隔缩短至24 h不影响流产效果,也未见药物不良反应增加。Objective To explore the effect on varying intervals of mifepristone combined with misoprostol for early pregnancy termination. Methods Totally 450 cases of early pregnancy were randomly divided into 3 groups. 150 cases in each group were orally administered 200 mg mifepristone and then followed with 0.6 mg misoprostol in 12, 24 and 48 hours later respectively. The efficacy and adverse reactions of three groups were observed. Results The complete abortion rates in group 1, group 2 and group 3 were 82.00%, 91.33% and 92.00% respectively. The complete abortion rates in the experimental group 1 was lower than group 2 or 3 （P〈0.01）. There were no serious adverse reactions observed in the three groups. Conclusion Mifepristone 200 mg followed 24 hours later by misoprostol 0.6 mg orally is as effective for abortion as compared with a 48-hour dosing interval. It is an effective and safer approach for abortion.

关 键 词：米非司酮 米索前列醇 间隔 早孕 终止 

分 类 号：R979.22[医药卫生—药品]