不孕妇女阴道念珠菌病致病菌分析  

Analysis of pathogenic fungi causing vulvovaginal candidiasis in infertility women

作　　者：唐晓华[1] 江镜全[1] 叶俊凯 蔡媛媛[2] 夏勇[1] 

机构地区：[1]广州医学院第三附属医院检验科,广东广州510150 [2]广州医学院检验系,广东广州510182

出　　处：《检验医学》2014年第2期115-117,共3页Laboratory Medicine

摘　　要：目的了解本地区不孕妇女外阴阴道念珠菌病(VVC)致病菌的菌种分布及药物敏感性情况,为临床治疗提供参考。方法采集不孕妇女阴道分泌物样本,留取念珠菌阳性样本,采用科玛嘉念珠菌显色培养基做培养鉴定,并采用Rosco纸片扩散法做药物敏感性试验。结果收集的454例样本中共分离出86株念珠菌,其中白念珠菌48株,占55.81%;光滑念珠菌24株,占27.91%;热带念珠菌8株,占9.30%;克柔念珠菌4株,占4.65%;近平滑念珠菌2株,占2.33%。分离的菌株对两性霉素B、克霉唑、咪康唑、氟康唑、伊曲康唑的敏感率分别为93.55%、77.91%、65.12%、62.79%、59.30%。结论非白念珠菌在不孕妇女VVC中分离率较高,不同菌种对不同抗菌药物敏感性有较大差异,临床应根据培养鉴定和药物敏感性结果合理使用抗真菌药物。Objective To investigate the distribution and drug resistance of pathogenic fungi causing vulvovaginal candidiasis（VVC）in infertility women,and provide the reference for clinical treatment.Methods The CHROMagar Candida color medium was applied to identify Candida isolated from the vaginal secretions collected from infertility women,and Rosco disc diffusion method was used for drug susceptibility.Results A total of 86 Candida isolates were isolated from 454 vaginal secretion samples,including 48 isolates of Candida albicans（55.81%）,24 isolates of Candida glabrata（27.91%）,8 isolates of Candida tropicalis （9.30%）,4 isolates of Candida krusei （4.65%）and 2 isolates of Candida parapsilosis （2.33%）.The sensitivity rates of Candida isolates to amphotericin B,ketoconazole,miconazole, fluconazole and itraconazole were 93.55%,77.91%,65.1 2%,62.79% and 59.30% respectively.Conclusions The non-Candida albicans infection in infertility women with VVC increases obviously,and the drug sensitivities of different types of Candida isolates are different.Therefore,antibiotic drugs should be carefully used being based on the results of fungal culture identification and drug sensitivity test.

关 键 词：念珠菌 药物敏感性试验 不孕 妇女 

分 类 号：R379.4[医药卫生—病原生物学]